{"id":"W4409629417","doi":"10.1158/1538-7445.am2025-6061","title":"Abstract 6061: Dual PD-L1 blockade and VEGF-A neutralization with the bispecific antibody BNT327/PM8002 shows potent antitumor activity in preclinical models","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"","keywords":"Blockade; Bispecific antibody; Medicine; Neutralization; Antibody; Cancer research; VEGF receptors; Pharmacology; Immunology; Internal medicine; Receptor; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002951279,0.0007544401,0.0006114729,0.0003097178,0.0001289065,0.0002459761,0.0003066907,0.00049726,0.001946936],"category_scores_gemma":[0.0001145964,0.0001942152,0.0002431742,0.0001683422,0.0002480858,0.0002710445,0.0001411336,0.001277958,0.0007328176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979735,"about_ca_system_score_gemma":0.0004049477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007111829,"about_ca_topic_score_gemma":0.0007225268,"domain_scores_codex":[0.9998171,0.00003087397,0.00001169854,0.00003518146,0.0000551887,0.00004999807],"domain_scores_gemma":[0.9999143,0.00001111871,0.00001586531,0.000008366343,0.0000116707,0.0000386796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009775233,0.0009088417,0.00008434066,0.00007318034,0.00001576445,0.0000414661,0.00001293322,0.0002791718,0.9925333,0.0001315982,0.0004963577,0.004445526],"study_design_scores_gemma":[0.0004108199,0.008676906,0.001288034,0.00001055079,0.00003519575,0.0003065836,0.00001057211,0.002243874,0.9836304,0.00006742691,0.003311848,0.000007733199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868425,0.002651588,0.004889129,0.0003105582,0.0001594499,0.000205904,0.0006976996,0.0003539181,0.003889272],"genre_scores_gemma":[0.9878814,0.001271909,0.003846613,0.0001408474,0.00003710665,0.0002697259,0.001339459,0.00004546818,0.005167447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001946936,"threshold_uncertainty_score":0.006513119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1270542841736797,"score_gpt":0.4546985707906712,"score_spread":0.3276442866169915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}