{"id":"W4409629571","doi":"10.1158/1538-7445.am2025-5644","title":"Abstract 5644: Identification of alexidine as a novel small molecule inhibitor of TAZ-TEAD interaction in breast cancer cell migration","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Breast cancer; Identification (biology); Cancer research; Cancer; Medicine; Biology; Oncology; Computational biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238192,0.0003826693,0.0003920227,0.0002105919,0.0001705954,0.0001875355,0.0003378424,0.0003780847,0.0018618],"category_scores_gemma":[0.000105241,0.0001190556,0.0003121337,0.0001710252,0.0001322383,0.0001910835,0.0001990396,0.0005485153,0.0004635524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601897,"about_ca_system_score_gemma":0.0002110712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005833344,"about_ca_topic_score_gemma":0.0008584408,"domain_scores_codex":[0.9999021,0.00001245728,0.000009353247,0.00002429539,0.00003202722,0.00001979607],"domain_scores_gemma":[0.9999644,0.000007020522,0.000007143358,0.000003320871,0.000008257229,0.000009896643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008871638,0.00004894256,0.0001008203,0.0001012755,0.00001040016,0.00004439402,0.000009291472,0.00008028696,0.9948224,0.0001243799,0.0002344096,0.004334671],"study_design_scores_gemma":[0.00004250471,0.0004822365,0.00146202,0.000007455581,0.00002168637,0.0002188528,0.000009409128,0.001168117,0.9912754,0.00002801933,0.005275718,0.000008458768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9552092,0.0165484,0.01624862,0.0007362392,0.0003250719,0.0002465398,0.001072208,0.0005537118,0.009059881],"genre_scores_gemma":[0.9703053,0.005435571,0.01320179,0.0003087837,0.00003710884,0.0001502397,0.001384577,0.00003642852,0.009140212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018618,"threshold_uncertainty_score":0.006228387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03986098455402925,"score_gpt":0.3767249792686187,"score_spread":0.3368639947145894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}