{"id":"W4409629788","doi":"10.1158/1538-7445.am2025-4380","title":"Abstract 4380: HBW-016-K, a novel orally available pan-KRAS inhibitor targeting both “ON” and “OFF” states, is potent, selective, efficacious, safe, and high tissue-penetrant","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hyperion Technologies (Canada)","funders":"","keywords":"Penetrant (biochemical); Pharmacology; Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009811765,0.0004943053,0.0002765584,0.0001824367,0.0001029699,0.0002370209,0.0003376577,0.000300236,0.004792915],"category_scores_gemma":[0.00004982351,0.0001376082,0.0001969038,0.0002120513,0.0001716257,0.0002583158,0.0001939284,0.0006447113,0.00185906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002513418,"about_ca_system_score_gemma":0.0003672596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006303444,"about_ca_topic_score_gemma":0.0008179944,"domain_scores_codex":[0.9999367,0.000006322271,0.000005111598,0.00001399007,0.00002340716,0.00001444853],"domain_scores_gemma":[0.9999731,0.000001604477,0.000009371044,0.000001783884,0.00000635409,0.000007770477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001026023,0.000433038,0.0006554857,0.0006409141,0.00003443673,0.0003254121,0.00002897243,0.000904361,0.9483438,0.0007922884,0.002117435,0.04469781],"study_design_scores_gemma":[0.0005677619,0.004482609,0.004391041,0.0000387308,0.00009098843,0.002099985,0.00002395755,0.001967387,0.9526073,0.0001602945,0.03354106,0.00002882112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9306434,0.01482416,0.01690361,0.0008179463,0.0002051489,0.0004508955,0.00335532,0.0007984859,0.03200113],"genre_scores_gemma":[0.9551426,0.007316912,0.006422517,0.0003692676,0.00004500754,0.0001114057,0.00341518,0.00005337932,0.02712372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004792915,"threshold_uncertainty_score":0.01603395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04153205169861886,"score_gpt":0.3918370502591069,"score_spread":0.350304998560488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}