{"id":"W4409629816","doi":"10.1172/jci.insight.178754","title":"Glycine receptor activation promotes pancreatic islet cell proliferation via the PI3K/mTORC1/p70S6K pathway","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Department of Education of Zhejiang Province; National Natural Science Foundation of China","keywords":"mTORC1; PI3K/AKT/mTOR pathway; Islet; Cell biology; Glycine; Cell growth; Chemistry; Receptor; Pancreatic islets; Cancer research; Signal transduction; Endocrinology; Biochemistry; Biology; Diabetes mellitus; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002202799,0.0002152879,0.0003280205,0.0001657031,0.0002220549,0.00005542203,0.00009050604,0.0001425856,0.000727896],"category_scores_gemma":[0.0004416202,0.0001344204,0.00009206174,0.0005433873,0.00006389397,0.0001679294,0.00003208941,0.0002390403,0.0002176962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001335853,"about_ca_system_score_gemma":0.0002540229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003319969,"about_ca_topic_score_gemma":0.000002859408,"domain_scores_codex":[0.9986857,0.00011198,0.000361584,0.0003077867,0.0002931615,0.000239748],"domain_scores_gemma":[0.9988897,0.000240967,0.0001279162,0.0004574185,0.0002014442,0.00008248664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005292248,0.0006846121,0.01350835,0.0004475235,0.0001690314,0.0000031321,0.001362792,0.000008325199,0.9233484,0.002987116,0.04698443,0.009967113],"study_design_scores_gemma":[0.002179673,0.0004979,0.006565201,0.0002751829,0.0001550177,0.000003305998,0.0001822208,0.001239224,0.8539067,0.0006530852,0.1341519,0.0001905606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8875476,0.0004380269,0.004392593,0.0086582,0.0005883222,0.001615326,0.000006441307,0.0002440822,0.09650944],"genre_scores_gemma":[0.9654706,0.00003968032,0.0005620716,0.003289608,0.0004473764,0.0002078797,0.0001463566,0.00002343934,0.02981305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08716749,"threshold_uncertainty_score":0.796995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121989536025476,"score_gpt":0.2322694968756225,"score_spread":0.2210496015153677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}