{"id":"W4409629821","doi":"10.1158/1538-7445.am2025-6106","title":"Abstract 6106: A regulated, cell-intrinsic cytokine engineering strategy to enhance the in vitro and in vivo persistence of iPSC-derived CAR-T cell therapies","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"iCo Therapeutics (Canada)","funders":"","keywords":"In vivo; Persistence (discontinuity); Cytokine; In vitro; Cell; Immunology; Cell biology; Biology; Cancer research; Medicine; Genetics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002087099,0.0003947993,0.0002404553,0.0003067398,0.0001281482,0.0004435164,0.0002721071,0.0005051233,0.00169844],"category_scores_gemma":[0.0001277414,0.0001281441,0.000278619,0.0002006909,0.0001954504,0.0002202085,0.0002052437,0.0007811576,0.000872321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356844,"about_ca_system_score_gemma":0.0002476278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001590429,"about_ca_topic_score_gemma":0.0001692732,"domain_scores_codex":[0.9997891,0.00002470963,0.00003257381,0.00003967892,0.00007866089,0.00003533083],"domain_scores_gemma":[0.9998831,0.0000197119,0.00004047531,0.00001566164,0.00002054991,0.00002048978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000204611,0.00002856803,0.00005129467,0.00002357941,0.000002705829,0.00003533577,0.00001005416,0.0001751998,0.9975182,0.0002277741,0.00006975549,0.001837084],"study_design_scores_gemma":[0.000009551783,0.0000980154,0.0002283142,0.000003121885,0.00001050236,0.000111666,0.000004742489,0.001117147,0.9958382,0.0000300963,0.002545513,0.000003217662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9290621,0.001423145,0.06055555,0.0002484608,0.0001401387,0.0002768162,0.0009827894,0.0005077001,0.00680335],"genre_scores_gemma":[0.9700117,0.0007425246,0.02187348,0.0001341426,0.0000236523,0.0001646288,0.0007767596,0.0001137364,0.006159272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169844,"threshold_uncertainty_score":0.005681813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03800978810852777,"score_gpt":0.3533295094371943,"score_spread":0.3153197213286665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}