{"id":"W4409630656","doi":"10.1158/1538-7445.am2025-4623","title":"Abstract 4623: The relationship of KRAS mutation and clinical outcomes in patients treated with consolidation durvalumab for locally advanced non-small cell lung cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Durvalumab; Medicine; Lung cancer; Oncology; Internal medicine; KRAS; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002780037,0.000133516,0.0002479465,0.0002521509,0.0002147149,0.00039276,0.0002385335,0.000229984,0.001843467],"category_scores_gemma":[0.001195233,0.00008978177,0.0002205203,0.0004139908,0.0001834495,0.0002915129,0.0001680524,0.0004144241,0.0002663626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005673484,"about_ca_system_score_gemma":0.0003088656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002618986,"about_ca_topic_score_gemma":0.004670958,"domain_scores_codex":[0.999815,0.00003317927,0.00002282438,0.00004213022,0.00004753898,0.00003919856],"domain_scores_gemma":[0.999018,0.000167382,0.0005033521,0.00002615181,0.00007104786,0.0002139699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004895231,0.00002854103,0.997256,0.000008362423,0.00003210209,0.00008053274,0.00001654112,0.000052458,0.0002191093,0.000005668333,0.0001152246,0.001696046],"study_design_scores_gemma":[0.00002154483,0.0002902572,0.9987477,0.000006037653,0.00003212066,0.0003528282,0.00003788646,0.0002012226,0.0001145652,0.00001192238,0.0001815526,0.000002357244],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993029,0.0002117407,0.00001452314,0.00003848795,0.00000344317,0.000003166656,0.0001758812,0.000001644209,0.0002482327],"genre_scores_gemma":[0.9996492,0.00003777123,0.00001210946,0.00001126302,0.000005327808,0.000002442405,0.0001989405,5.924249e-7,0.00008239161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002618986,"threshold_uncertainty_score":0.006167054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05941239134378427,"score_gpt":0.4702794653159846,"score_spread":0.4108670739722003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}