{"id":"W4409631380","doi":"10.1158/1538-7445.am2025-4876","title":"Abstract 4876: Avidity engineered multispecific antibodies that are highly efficacious in immune cell stimulation in patient tissue and in mice: significantly improved tumor control and turning cold tumors hot","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Avidity; Immune system; Antibody; Stimulation; Co-stimulation; Medicine; Immunology; Cancer research; Cell; T cell; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002146774,0.0006512294,0.000318766,0.000236975,0.00008145809,0.000240119,0.0002470957,0.0004023385,0.00279694],"category_scores_gemma":[0.00007847874,0.0001506249,0.0002388617,0.0001274445,0.0001644526,0.0001940212,0.0001508786,0.0006404278,0.0007191416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003018685,"about_ca_system_score_gemma":0.0001662939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002408524,"about_ca_topic_score_gemma":0.0003392205,"domain_scores_codex":[0.9998776,0.00001549244,0.000007310555,0.00002686259,0.0000396016,0.00003322656],"domain_scores_gemma":[0.9999205,0.00001036467,0.00002809551,0.00001016343,0.000008722986,0.00002215151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001941768,0.0001112036,0.00007377699,0.00004387003,0.000008722282,0.00004551203,0.000008242087,0.0001551094,0.9954726,0.0001157611,0.0003851691,0.00338577],"study_design_scores_gemma":[0.00009162895,0.0009737606,0.0009484466,0.000005837188,0.00001777152,0.0003913887,0.000003157955,0.0005563039,0.9932013,0.00002613545,0.003779963,0.000004335303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730857,0.003293551,0.01368524,0.0004123145,0.000129138,0.0001587523,0.001008058,0.0006073369,0.007619957],"genre_scores_gemma":[0.9758744,0.001586386,0.008758486,0.0001840986,0.00004150223,0.0001021824,0.001029839,0.00007909731,0.01234406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00279694,"threshold_uncertainty_score":0.009356737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01785870181254681,"score_gpt":0.321539973529425,"score_spread":0.3036812717168783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}