{"id":"W4409631479","doi":"10.1158/1538-7445.am2025-5431","title":"Abstract 5431: The mitochondrial protease, YME1L regulates interferon signaling and is essential for AML growth and differentiation","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Interferon; Biology; Cell biology; Protease; Cancer research; Immunology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191839,0.0004847703,0.0003418265,0.0002209619,0.000308974,0.0003495747,0.0002018744,0.0003541214,0.004632314],"category_scores_gemma":[0.0001129785,0.0001292392,0.000240145,0.0002210778,0.0001830953,0.0002023614,0.0003043825,0.0005616559,0.002449804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004867766,"about_ca_system_score_gemma":0.0002174637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004300511,"about_ca_topic_score_gemma":0.0004486974,"domain_scores_codex":[0.9998677,0.00001250749,0.0000177181,0.00003673266,0.00003819414,0.0000271159],"domain_scores_gemma":[0.9998865,0.000009146445,0.00004669398,0.000008921915,0.00001732801,0.00003133848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001739644,0.0000132833,0.0003460459,0.0000720879,0.000003307875,0.00009917969,0.00001047946,0.00003486286,0.9964389,0.000089833,0.0003360483,0.002382078],"study_design_scores_gemma":[0.00005025572,0.0001739955,0.01752269,0.00002558894,0.00001775005,0.0006848958,0.00004077213,0.0008575581,0.9645902,0.00008897269,0.01593867,0.00000863055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613588,0.01046329,0.008460739,0.001124612,0.0002589842,0.00008817229,0.01104348,0.000726868,0.006475027],"genre_scores_gemma":[0.9670354,0.002219217,0.00396725,0.0002855922,0.00004384617,0.00007650534,0.01056847,0.0001240895,0.01567977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004632314,"threshold_uncertainty_score":0.01549667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03008880398819404,"score_gpt":0.3513723310674072,"score_spread":0.3212835270792132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}