{"id":"W4409631610","doi":"10.1158/1538-7445.am2025-7318","title":"Abstract 7318: ZW209, a DLL3 targeted trispecific T cell engager with integrated CD28 co-stimulation, demonstrates safety and potent preclinical efficacy in models of small cell lung cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Medicine; Stimulation; Cancer; Cell; Cancer research; Co-stimulation; Pharmacology; Oncology; T cell; CD28; Biology; Internal medicine; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316559,0.0005046839,0.0002684058,0.000266957,0.000154972,0.0002253579,0.0002659299,0.0004595836,0.004054935],"category_scores_gemma":[0.00006819813,0.0001250405,0.0002363849,0.0001516317,0.0001681436,0.0002158222,0.0001349584,0.0007076211,0.001174751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003739441,"about_ca_system_score_gemma":0.0005131659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009835633,"about_ca_topic_score_gemma":0.001273101,"domain_scores_codex":[0.9998755,0.00001237935,0.000009065513,0.00002187471,0.00004073131,0.00004037862],"domain_scores_gemma":[0.9999391,0.000005382936,0.00001946823,0.000004834653,0.000009876385,0.0000214255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006672128,0.0002988256,0.000158273,0.00006712758,0.000009499484,0.00007822007,0.00001173642,0.0002756186,0.9923503,0.0002070215,0.0008611645,0.00501507],"study_design_scores_gemma":[0.0001264275,0.002010532,0.0008616156,0.000005307214,0.0000176453,0.00028181,0.0000100352,0.000866874,0.9913846,0.00004637795,0.004383309,0.000005404571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803711,0.001151807,0.005682329,0.0004509695,0.0001247059,0.0002112158,0.002399286,0.0006161169,0.008992529],"genre_scores_gemma":[0.9825263,0.000804898,0.003852333,0.0001814103,0.00002318044,0.0001798096,0.002264462,0.00008201816,0.01008567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004054935,"threshold_uncertainty_score":0.01356512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.090157316433527,"score_gpt":0.4251451087888187,"score_spread":0.3349877923552917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}