{"id":"W4409631974","doi":"10.1158/1538-7445.am2025-2171","title":"Abstract 2171: Amezalpat, a peroxisome proliferator-activated receptor alpha (PPARα) antagonist, inhibits suppressive macrophage development, activation and function","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre","funders":"","keywords":"Peroxisome proliferator-activated receptor; Peroxisome; Antagonist; Chemistry; Receptor; Alpha (finance); Function (biology); Peroxisome proliferator; Peroxisome proliferator-activated receptor alpha; Cell biology; Pharmacology; Endocrinology; Cancer research; Biology; Medicine; Biochemistry; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468223,0.0006995588,0.0005733119,0.0002852559,0.0001706883,0.0002538961,0.0003838943,0.0004666038,0.005678358],"category_scores_gemma":[0.0001501501,0.0001777985,0.0003885077,0.0002351017,0.0002818421,0.0002522067,0.0001680549,0.00109091,0.001664156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207385,"about_ca_system_score_gemma":0.0004673672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004302022,"about_ca_topic_score_gemma":0.000531039,"domain_scores_codex":[0.9998496,0.0000269415,0.00001425237,0.00002207267,0.00003554162,0.00005154485],"domain_scores_gemma":[0.9999042,0.00001889001,0.00002450795,0.00001120153,0.00001101317,0.00003027573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006228494,0.001219086,0.0002276125,0.0002426949,0.00004020475,0.0002175368,0.00002891372,0.0001635783,0.9795622,0.0001451662,0.001083852,0.01084057],"study_design_scores_gemma":[0.001538705,0.01702817,0.005884144,0.00002475835,0.00008655328,0.0009504731,0.00004980633,0.0009135212,0.9659283,0.000100332,0.007482973,0.00001232599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861397,0.002884462,0.002327986,0.0005053444,0.0002368603,0.0001483858,0.002140956,0.0003621653,0.005254179],"genre_scores_gemma":[0.9804795,0.002312066,0.002408999,0.0003666664,0.0001439321,0.0002474867,0.004367842,0.00006396721,0.009609546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005678358,"threshold_uncertainty_score":0.018996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02680946258330607,"score_gpt":0.3400124083423511,"score_spread":0.313202945759045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}