{"id":"W4409632064","doi":"10.1158/1538-7445.am2025-5173","title":"Abstract 5173: Heterozygous <i>Ppp2r1a</i> mutations with concurrent loss of Tp53 drive invasive high-grade uterine cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer; Medicine; Uterine cancer; Gynecologic cancer; Internal medicine; Oncology; Biology; Ovarian cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216169,0.0005403244,0.0002906939,0.0005801074,0.0004839302,0.0006293014,0.0004912117,0.0009415546,0.01015292],"category_scores_gemma":[0.0003408525,0.0003494306,0.0005738047,0.0002997955,0.0006133307,0.0002066919,0.0004297991,0.001222555,0.002945692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004150809,"about_ca_system_score_gemma":0.0003482181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001633028,"about_ca_topic_score_gemma":0.00227947,"domain_scores_codex":[0.9996747,0.00003914013,0.00003755328,0.00008226894,0.0000962964,0.00007014591],"domain_scores_gemma":[0.9996912,0.00006999658,0.00008630146,0.00003987859,0.00001715075,0.00009544715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003460565,0.0004119368,0.002439225,0.0001000614,0.00005807791,0.006415805,0.0001290234,0.0004586796,0.9763396,0.002750328,0.003541598,0.007009651],"study_design_scores_gemma":[0.0005151838,0.002327645,0.04608324,0.0001388841,0.0002590899,0.0520163,0.0006954274,0.01022577,0.8248682,0.002302176,0.06046893,0.00009907586],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9524902,0.001114016,0.01200269,0.001368769,0.0005452855,0.0004505481,0.00686154,0.001399636,0.02376723],"genre_scores_gemma":[0.9822645,0.0005357452,0.002008379,0.0004542494,0.00004780061,0.000148047,0.001542456,0.0002356532,0.0127634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01015292,"threshold_uncertainty_score":0.03396493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02987482950077956,"score_gpt":0.3778002671468566,"score_spread":0.347925437646077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}