{"id":"W4409632265","doi":"10.1158/1538-7445.am2025-6947","title":"Abstract 6947: CRISPR/Cas9 kinome screen identifies PNKP as a novel fitness gene in HPV-negative head and neck squamous cell carcinoma","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Yukon University","funders":"","keywords":"CRISPR; Kinome; Head and neck squamous-cell carcinoma; Biology; Gene; Head and neck; Basal cell; Computational biology; Genetics; Cancer research; Medicine; Cancer; Head and neck cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752437,0.000332428,0.0003934194,0.0002803285,0.0002611061,0.0002761655,0.0002591027,0.0003873988,0.0023497],"category_scores_gemma":[0.0001956221,0.0001135541,0.0003224669,0.0001892172,0.0002244271,0.0001280716,0.0002696879,0.0004603603,0.0007461097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003543455,"about_ca_system_score_gemma":0.0002762912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152874,"about_ca_topic_score_gemma":0.001829202,"domain_scores_codex":[0.9997943,0.00001638349,0.00002148664,0.00005110697,0.00008801947,0.00002870948],"domain_scores_gemma":[0.9998887,0.00002624849,0.00002763131,0.00001459201,0.0000165061,0.00002641695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005642392,0.00002135704,0.000369548,0.00005829934,0.000007683293,0.0001718837,0.00001323096,0.0001889798,0.9969969,0.00009189355,0.00015157,0.00187214],"study_design_scores_gemma":[0.00001620788,0.0002030137,0.008159047,0.00001612799,0.00003705852,0.001110279,0.00004300897,0.003780611,0.9824089,0.0000722622,0.004136423,0.00001719572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725196,0.0005926582,0.0175465,0.0001647326,0.00006476473,0.0001639651,0.004080016,0.0006599299,0.004207639],"genre_scores_gemma":[0.9825814,0.0004000069,0.008450918,0.0001067241,0.000004467036,0.0001043655,0.003122476,0.0001198638,0.005109798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0023497,"threshold_uncertainty_score":0.007860541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05366410835365815,"score_gpt":0.3801940959541438,"score_spread":0.3265299876004856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}