{"id":"W4409633143","doi":"10.1158/1538-7445.am2025-5402","title":"Abstract 5402: Metabolic shift towards the <i>de novo</i> serine pathway in non-transformed breast cells drives epigenetic plasticity, oxidative DNA damage, and pro-tumorigenic cChanges associated with aging","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Epigenetics; DNA damage; Serine; Cancer research; Biology; Oxidative phosphorylation; Oxidative stress; Cell biology; Oxidative damage; DNA; Genetics; Gene; Biochemistry; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386179,0.0004637221,0.0004262456,0.0002654193,0.000335028,0.0004745543,0.0002080628,0.000357662,0.007683127],"category_scores_gemma":[0.0001168414,0.0001787363,0.000379393,0.0003912389,0.000199839,0.0002596786,0.0002470399,0.00055031,0.00197837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004147362,"about_ca_system_score_gemma":0.0003175012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423193,"about_ca_topic_score_gemma":0.001641242,"domain_scores_codex":[0.9998022,0.00001496015,0.00001312386,0.00007265387,0.00006391115,0.00003327825],"domain_scores_gemma":[0.9998981,0.00001197851,0.00002674721,0.0000107372,0.00002545761,0.00002697417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001068226,0.00001035907,0.000283752,0.0000499485,0.000005696379,0.00003175247,0.00001046911,0.00001231207,0.998384,0.00004378177,0.0002383403,0.0008226462],"study_design_scores_gemma":[0.00001973211,0.0002299883,0.03213793,0.00001658413,0.00003020927,0.0003521854,0.0000788772,0.0005698891,0.9566197,0.0001273194,0.009806758,0.00001084191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957979,0.00395913,0.008158587,0.0009673896,0.00040837,0.00007844308,0.01979162,0.0007878019,0.007869657],"genre_scores_gemma":[0.9306483,0.002573741,0.006770183,0.0005764622,0.00009873346,0.000153242,0.02794836,0.000303917,0.03092705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007683127,"threshold_uncertainty_score":0.0257026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549976636207546,"score_gpt":0.330969193061097,"score_spread":0.3054694266990216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}