{"id":"W4409633291","doi":"10.1158/1538-7445.am2025-6978","title":"Abstract 6978: Discovery and characterization of BAY-805, a potent and selective DUB inhibitor of ubiquitin specific peptidase USP21","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Ubiquitin; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958955,0.0005830745,0.0005654872,0.0004774207,0.0001739134,0.0003907532,0.0004087552,0.0004899122,0.002570281],"category_scores_gemma":[0.0001343795,0.000172856,0.000381539,0.0003472781,0.0001465659,0.000294938,0.0003135139,0.0007238397,0.001325173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003268986,"about_ca_system_score_gemma":0.0003340024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008226917,"about_ca_topic_score_gemma":0.001082883,"domain_scores_codex":[0.9998965,0.00001006355,0.000009879092,0.00002027774,0.00003771265,0.00002560991],"domain_scores_gemma":[0.9999436,0.000004110357,0.000009496766,0.000006064359,0.0000114849,0.00002517114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002104828,0.0003640666,0.000298704,0.0001774887,0.0000307786,0.000288633,0.00002526737,0.0007145726,0.9802862,0.0002653533,0.0009824344,0.01635618],"study_design_scores_gemma":[0.000496056,0.004833667,0.003502285,0.00003315871,0.0001213072,0.001149406,0.00002088565,0.003672835,0.958317,0.0002585465,0.02755904,0.00003584088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558917,0.01454504,0.01069907,0.0007606767,0.0001584737,0.0005894491,0.004581886,0.000557837,0.01221589],"genre_scores_gemma":[0.965042,0.007534671,0.009178031,0.0005457514,0.00005120027,0.0001927647,0.006575035,0.00006466811,0.01081586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002570281,"threshold_uncertainty_score":0.008598387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02749296183977314,"score_gpt":0.3250028926276652,"score_spread":0.2975099307878921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}