{"id":"W4409633723","doi":"10.1158/1538-7445.am2025-3033","title":"Abstract 3033: Increased mitochondrial protein import necessitates greater reliance on the mitochondrial unfolded protein response (UPRmt) and the protease LONP1 to maintain mitochondrial protein solubility and cell viability in acute myeloid leukemia (AML)","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Unfolded protein response; Mitochondrion; Myeloid leukemia; Cell biology; Cell; Protease; Biology; Chemistry; Cancer research; Endoplasmic reticulum; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007414952,0.0002308965,0.0003004281,0.0004354545,0.0002201773,0.000272469,0.00008700668,0.0001510823,0.001494871],"category_scores_gemma":[0.0001089885,0.00008133917,0.0002585203,0.0005835713,0.0001702621,0.0001353448,0.0001905245,0.0003063561,0.0005185053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791287,"about_ca_system_score_gemma":0.0002127248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005225373,"about_ca_topic_score_gemma":0.0006278466,"domain_scores_codex":[0.999897,0.000007887609,0.000008995896,0.00002611234,0.00003828384,0.00002176412],"domain_scores_gemma":[0.9999044,0.000014284,0.00003936765,0.000006662789,0.00001345702,0.00002179351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002600407,0.00001401188,0.003165195,0.00007163925,0.00000669094,0.0001640341,0.00002118919,0.0000945483,0.9936997,0.00005022074,0.0001595049,0.002293321],"study_design_scores_gemma":[0.00002148301,0.0003512977,0.142051,0.00001850696,0.00005047176,0.001684314,0.0001507841,0.001410299,0.8484802,0.0001792426,0.005590057,0.00001234157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910393,0.0006724445,0.002041271,0.00009758801,0.00001774712,0.00002636984,0.00523956,0.0001304688,0.0007353054],"genre_scores_gemma":[0.9821422,0.0005463809,0.004072352,0.00009787152,0.00001477463,0.00004396937,0.01093726,0.00004990067,0.002095401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494871,"threshold_uncertainty_score":0.005000889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01826974794197552,"score_gpt":0.3073432855539163,"score_spread":0.2890735376119408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}