{"id":"W4409633765","doi":"10.1158/1538-7445.am2025-6429","title":"Abstract 6429: Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Colorectal cancer; Medicine; Observational study; ANGPTL4; Oncology; Internal medicine; Cancer; Cancer research; Bioinformatics; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003361939,0.0003034058,0.0004409521,0.0004702548,0.0002128397,0.0005262408,0.0004042945,0.0003058224,0.005417195],"category_scores_gemma":[0.00592418,0.0001609669,0.0008955043,0.0007135695,0.0003515494,0.0001640698,0.0003588218,0.0005681341,0.0004263011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716794,"about_ca_system_score_gemma":0.0004669725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001966923,"about_ca_topic_score_gemma":0.00153925,"domain_scores_codex":[0.9983095,0.0009327313,0.0001010365,0.0003694851,0.0002329985,0.00005428816],"domain_scores_gemma":[0.9946727,0.002176702,0.001909563,0.0007389949,0.0002873419,0.0002147663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0124282,0.0001389426,0.8921835,0.001112729,0.009400616,0.0005031977,0.0000715288,0.001237382,0.02127746,0.001496564,0.004996402,0.05515336],"study_design_scores_gemma":[0.0006918772,0.001288856,0.97142,0.0001430928,0.006194733,0.00128908,0.00007120397,0.003240071,0.00584761,0.001691726,0.008100576,0.00002110741],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603689,0.009340546,0.01442603,0.001961673,0.0002101212,0.0001370316,0.007745361,0.0003105535,0.005499828],"genre_scores_gemma":[0.9949768,0.0007763758,0.001944755,0.0002820126,0.00007544037,0.00003587258,0.001162567,0.00003109168,0.0007149952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005417195,"threshold_uncertainty_score":0.01812232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1654968424128427,"score_gpt":0.4832495256997687,"score_spread":0.3177526832869261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}