{"id":"W4409633911","doi":"10.1158/1538-7445.am2025-7399","title":"Abstract 7399: Polygenic risk score-based smoking and drinking behaviors and head and neck squamous cell cancer risk by HPV status","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cardiovascular Health and Risk Factors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto; Sinai Health System; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Polygenic risk score; Squamous cell cancer; Head and neck cancer; Oncology; Internal medicine; Cancer; Head and neck; Basal cell; Surgery; Biology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118686,0.0002383054,0.0004707391,0.0003856064,0.000626533,0.0001037528,0.00008675372,0.0002128628,0.0001234931],"category_scores_gemma":[0.0001669102,0.0002059391,0.0001040511,0.0004884517,0.000374735,0.00007947043,0.0001179462,0.001405188,0.000001522811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004838646,"about_ca_system_score_gemma":0.00123807,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.102661,"about_ca_topic_score_gemma":0.006795903,"domain_scores_codex":[0.9971178,0.0002048346,0.0003167438,0.0006749711,0.0007008546,0.0009848005],"domain_scores_gemma":[0.9983593,0.0002846885,0.00008814547,0.0004094104,0.0001933664,0.0006651473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004134066,0.00005417388,0.8888329,0.0006459762,0.00007859388,0.00003079835,0.0003792608,0.00002196689,0.001975404,0.000001944159,0.0009801098,0.1065855],"study_design_scores_gemma":[0.004810716,0.0001840698,0.9765196,0.000375507,0.0003043957,0.000004374049,0.0002657984,0.00009342414,0.005759596,0.0000214648,0.0114588,0.0002022238],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8760903,0.1220641,0.00001756137,0.0002964113,0.0001943855,0.0008037628,0.0002029626,0.00003937497,0.0002911262],"genre_scores_gemma":[0.9403644,0.05887086,0.00003628766,0.0001398927,0.000124312,0.0001509528,0.00002032992,0.00004029713,0.0002526314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1063832,"threshold_uncertainty_score":0.9033144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0328051956307621,"score_gpt":0.3844168502546197,"score_spread":0.3516116546238576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}