{"id":"W4409634212","doi":"10.1158/1538-7445.am2025-6114","title":"Abstract 6114: Engineering novel synNotch CAR T cells to precisely and effectively target medulloblastoma","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medulloblastoma; Cancer research; Neuroscience; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006954014,0.0002156877,0.0001080549,0.0001164608,0.00007592966,0.0002192244,0.000151607,0.0002563946,0.001203797],"category_scores_gemma":[0.00005677868,0.00006565788,0.0001109576,0.00008327554,0.000102209,0.0001082643,0.000135999,0.0003041649,0.0003329678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702879,"about_ca_system_score_gemma":0.0001832123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007879722,"about_ca_topic_score_gemma":0.001041509,"domain_scores_codex":[0.9999254,0.000008807228,0.000005693065,0.0000154072,0.00002328667,0.00002144751],"domain_scores_gemma":[0.999972,0.00000330468,0.000008457268,0.000003141536,0.000005654376,0.000007499516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005527164,0.00002925589,0.0001664557,0.00002589564,0.000003018449,0.00004241033,0.00001510864,0.0004334619,0.9973757,0.0001753113,0.00009624506,0.001581859],"study_design_scores_gemma":[0.00003804979,0.0005011738,0.001431282,0.000005124919,0.00001381451,0.0002490011,0.00002591694,0.003549967,0.9887454,0.00004529323,0.005391365,0.000003569022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890055,0.0004889131,0.007659062,0.00006966077,0.00002589344,0.000109084,0.0002611762,0.00009700131,0.002283672],"genre_scores_gemma":[0.9920731,0.0002593691,0.004865158,0.00003435811,0.000005334738,0.00004819279,0.0002645366,0.00001398989,0.002436015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203797,"threshold_uncertainty_score":0.004027128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648570921860125,"score_gpt":0.3855703810788288,"score_spread":0.3490846718602276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}