{"id":"W4409634883","doi":"10.3390/jpm15040161","title":"Patient Experience with Intranasal Esketamine in Treatment-Resistant Depression: Insights from a Multicentric Italian Study (REAL-ESKperience)","year":2025,"lang":"en","type":"article","venue":"Journal of Personalized Medicine","topic":"Treatment of Major Depression","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Università degli Studi di Brescia; Università Cattolica del Sacro Cuore; Università di Catania","keywords":"Mood; Treatment-resistant depression; Clinical psychology; Depression (economics); Medicine; Psychology; Quality of life (healthcare); Psychiatry; Major depressive disorder; Psychotherapist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001483509,0.0002629037,0.0003586399,0.0005656554,0.0005683115,0.0006288023,0.0002994313,0.0004094111,0.00129811],"category_scores_gemma":[0.002429641,0.0002067857,0.0004506563,0.0006512586,0.0004935469,0.0003654468,0.0007542849,0.0003438113,0.0002266186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006631589,"about_ca_system_score_gemma":0.0004884262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004210497,"about_ca_topic_score_gemma":0.008057489,"domain_scores_codex":[0.9991308,0.0005416972,0.00004667097,0.0000710151,0.00008166527,0.0001280784],"domain_scores_gemma":[0.9984426,0.0003549234,0.0006008684,0.00008187265,0.0001322968,0.0003874574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001145485,0.001656124,0.9473684,0.0001872706,0.0001238659,0.001525818,0.02654248,0.00009671393,0.001175289,0.00006928635,0.001251264,0.01885814],"study_design_scores_gemma":[0.0001109893,0.002163595,0.9832123,0.00003062156,0.00004734296,0.00143626,0.01163971,0.0001899155,0.0001033691,0.00001855718,0.001026546,0.00002077191],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995794,0.00007616315,0.00002247187,0.00004000034,0.000001535731,0.0000186916,0.0000462059,8.116722e-7,0.0002147806],"genre_scores_gemma":[0.9993893,0.0001584795,0.00008201494,0.00009792576,0.00001005895,0.000031493,0.0001047509,0.000001709971,0.0001242106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004210497,"threshold_uncertainty_score":0.008372009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387266153391367,"score_gpt":0.3075521695347202,"score_spread":0.2936795080008066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}