{"id":"W4409635172","doi":"10.1158/1538-7445.am2025-6707","title":"Abstract 6707: Direct <i>in vivo</i> CRISPR screen identifies <i>BAP1</i> and <i>FAT1</i> as potent tumor suppressors in sarcomagenesis","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CRISPR; In vivo; BAP1; Biology; Medicine; Cancer; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002959495,0.0007904735,0.000502817,0.0006607443,0.0003475022,0.0005208647,0.0005229209,0.0007587001,0.006282099],"category_scores_gemma":[0.0002189181,0.0003003193,0.0005970166,0.000344931,0.0004573107,0.0002639199,0.0005773776,0.001296545,0.002828249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000391097,"about_ca_system_score_gemma":0.0004076955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001271219,"about_ca_topic_score_gemma":0.001799751,"domain_scores_codex":[0.9994486,0.00005089623,0.00005753752,0.0001262914,0.000223117,0.00009354405],"domain_scores_gemma":[0.9997188,0.00005430832,0.00008421543,0.0000382711,0.00003437811,0.00006994967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004126926,0.00002421054,0.0001355671,0.00004138596,0.000007636798,0.00008607037,0.00001161763,0.00006593985,0.9979275,0.0001650871,0.0002121773,0.001281442],"study_design_scores_gemma":[0.00001678803,0.0001559411,0.001872927,0.00001097895,0.00003386211,0.0005404031,0.00002172866,0.0008684724,0.9883639,0.00006188119,0.008041427,0.00001179852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8856254,0.002190764,0.0703053,0.0007117488,0.0003584744,0.0005222138,0.01442156,0.005125029,0.02073968],"genre_scores_gemma":[0.9262274,0.001618228,0.02484484,0.0004900176,0.0000372286,0.0003851858,0.01431998,0.001216125,0.03086102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006282099,"threshold_uncertainty_score":0.0210157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894819432959417,"score_gpt":0.3523476866498208,"score_spread":0.3333994923202266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}