{"id":"W4409635523","doi":"10.1158/1538-7445.am2025-5437","title":"Abstract 5437: N-myristoylation inhibitor zelenirstat reduces mitochondrial complex I activity, OXPHOS, glycolysis, and cancer stem cell growth in triple-negative breast cancer (TNBC) cells","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada); University of Alberta","funders":"","keywords":"Triple-negative breast cancer; Cancer; Stem cell; Cancer research; Cancer stem cell; Oxidative phosphorylation; Breast cancer; Glycolysis; Medicine; Myristoylation; Biology; Internal medicine; Biochemistry; Cell biology; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000087274,0.0003885468,0.0004209515,0.0002203474,0.0001335031,0.0002285256,0.0002152158,0.0002971349,0.00263053],"category_scores_gemma":[0.00008411588,0.000152398,0.0003071129,0.0002111291,0.0001792092,0.0001829092,0.0001601981,0.000681714,0.0006366507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004048941,"about_ca_system_score_gemma":0.0003045837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968562,"about_ca_topic_score_gemma":0.002431909,"domain_scores_codex":[0.9998692,0.00001085929,0.00001644734,0.00002787855,0.00004258397,0.00003297564],"domain_scores_gemma":[0.9999267,0.000008175686,0.00002097369,0.000007733361,0.000009069255,0.00002735175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002837645,0.00004115295,0.0001262577,0.0000393605,0.000009264929,0.00002540331,0.000009126606,0.00006479937,0.9979252,0.00003059423,0.0001939453,0.001251171],"study_design_scores_gemma":[0.00003568213,0.0004071099,0.003027074,0.000004996792,0.0000212003,0.0001187851,0.00002116159,0.0005448182,0.9936746,0.00001665734,0.002123581,0.000004305869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924526,0.001748556,0.001025685,0.0002268066,0.00006012872,0.00003336654,0.002123981,0.0003672951,0.001961706],"genre_scores_gemma":[0.9899684,0.0009970168,0.001195684,0.0001151107,0.00000850667,0.00005533995,0.002935079,0.00005546708,0.004669443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00263053,"threshold_uncertainty_score":0.00880003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06217476182250717,"score_gpt":0.4045219016292207,"score_spread":0.3423471398067135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}