{"id":"W4409635531","doi":"10.1158/1538-7445.am2025-7130","title":"Abstract 7130: Spatially resolved single-cell analysis reveals cGAS-STING-mediated tumor-immune interactions via IFNα as determinants of pembrolizumab sensitivity in triple-negative breast cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Pembrolizumab; Immune system; Medicine; Breast cancer; Cancer; Cancer research; Triple-negative breast cancer; Oncology; Internal medicine; Immunology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200876,0.00009739623,0.0001729551,0.0002352511,0.0001393544,0.0002426505,0.000108409,0.0001635366,0.0009135986],"category_scores_gemma":[0.0001229986,0.0000830196,0.0001157287,0.0001884926,0.0001100927,0.00007098656,0.0001063445,0.0001772521,0.0002195712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081556,"about_ca_system_score_gemma":0.0001161645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00099095,"about_ca_topic_score_gemma":0.001874054,"domain_scores_codex":[0.9999323,0.000007252525,0.000003185472,0.00002233217,0.0000208651,0.00001400873],"domain_scores_gemma":[0.9999545,0.000008241633,0.00001074196,0.000006065767,0.00001075051,0.000009823988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002889332,0.00002201516,0.01205597,0.00003217172,0.0000140628,0.00007107869,0.0000514982,0.0002679613,0.9832811,0.00003378385,0.0001619728,0.003719439],"study_design_scores_gemma":[0.00002913212,0.0003494383,0.6270692,0.0000100138,0.0000686299,0.0007925146,0.000334134,0.01718197,0.3515827,0.0001457227,0.00242237,0.00001423166],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980561,0.00024934,0.0008992064,0.00002222673,0.000004537214,0.000007677663,0.0004367843,0.00003275938,0.0002914885],"genre_scores_gemma":[0.9974822,0.00008913819,0.001326502,0.0000259893,0.00000398253,0.00001543554,0.000620227,0.000008245331,0.0004282685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00099095,"threshold_uncertainty_score":0.003056288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03616361163697846,"score_gpt":0.3670689389749576,"score_spread":0.3309053273379792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}