{"id":"W4409635946","doi":"10.1158/1538-7445.am2025-6337","title":"Abstract 6337: A novel PMS2 mutant Lynch syndrome mouse model for cancer prevention studies","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lynch syndrome; PMS2; Cancer; Mutant; Cancer prevention; Medicine; Internal medicine; Genetics; Cancer research; Biology; Colorectal cancer; Gene; DNA mismatch repair","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008684393,0.001706515,0.001038809,0.003320647,0.001190058,0.0008872861,0.0010629,0.002878635,0.01950163],"category_scores_gemma":[0.0003273801,0.000941712,0.00155542,0.001089509,0.0007607808,0.00109006,0.0006798653,0.003374886,0.01013135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008739871,"about_ca_system_score_gemma":0.0005678285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001544326,"about_ca_topic_score_gemma":0.003042278,"domain_scores_codex":[0.9988292,0.0001095707,0.0001609843,0.0003255894,0.0003751826,0.0001995085],"domain_scores_gemma":[0.9990564,0.0001026953,0.0002093863,0.0001197311,0.0001422082,0.0003695913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008984159,0.001124057,0.001161275,0.0001892243,0.00007252189,0.001185065,0.0002455708,0.0003804491,0.9822747,0.002033021,0.003688143,0.006747652],"study_design_scores_gemma":[0.0009786423,0.003050162,0.01063976,0.000198174,0.0003556443,0.006403465,0.0004157637,0.005105256,0.8742378,0.001760391,0.09674608,0.0001088064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8232657,0.004525709,0.06982777,0.003781404,0.001638428,0.00250739,0.05992484,0.006408557,0.02812018],"genre_scores_gemma":[0.681724,0.00467202,0.05724339,0.001894202,0.0003066706,0.007219238,0.03971995,0.002302962,0.2049176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01950163,"threshold_uncertainty_score":0.06523943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2446293301402779,"score_gpt":0.5105526769991433,"score_spread":0.2659233468588654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}