{"id":"W4409643242","doi":"10.1101/2025.04.15.649049","title":"Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Key Research and Development Program of China; Leibniz-Gemeinschaft; Natural Sciences and Engineering Research Council of Canada; Office of Science; National Institutes of Health; Novo Nordisk Fonden; National Natural Science Foundation of China; European Synchrotron Radiation Facility; Deutsche Forschungsgemeinschaft; Argonne National Laboratory; Aarhus Universitet; U.S. Department of Energy; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Villum Fonden; National Institute of General Medical Sciences; Novo Nordisk; Common Fund; Gottfried Wilhelm Leibniz Universität Hannover; European Molecular Biology Laboratory; National Science Foundation","keywords":"Relevance (law); Nucleic acid; Nucleic acid structure; Computational biology; Business; Computer science; Chemistry; Risk analysis (engineering); Biology; RNA; Biochemistry; Political science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01521345,0.001320014,0.0008290451,0.001888332,0.0006607919,0.002790846,0.0009899192,0.001296091,0.006484905],"category_scores_gemma":[0.04863537,0.0002647919,0.0006238915,0.001004318,0.001139139,0.002017781,0.001340385,0.001019155,0.002569764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001355664,"about_ca_system_score_gemma":0.001196062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002578978,"about_ca_topic_score_gemma":0.001238823,"domain_scores_codex":[0.9920433,0.002914203,0.0006164514,0.001005962,0.002735399,0.0006846566],"domain_scores_gemma":[0.9666159,0.01947076,0.002410001,0.004784648,0.005518057,0.001200539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009387144,0.0005313481,0.4126336,0.000925411,0.0008888873,0.001707574,0.0006380098,0.3549885,0.03019594,0.01407398,0.04160723,0.1324224],"study_design_scores_gemma":[0.000566575,0.001281439,0.0876452,0.0001679297,0.0002337991,0.002032734,0.000889128,0.8060793,0.06608194,0.02230423,0.01256456,0.0001532309],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563331,0.001538198,0.01766181,0.001407531,0.0002635765,0.0001029392,0.005870859,0.003157801,0.01366416],"genre_scores_gemma":[0.9860693,0.0001409529,0.004744676,0.00009019558,0.00002346282,0.00001864592,0.007659269,0.0002639726,0.000989407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01521345,"threshold_uncertainty_score":0.08045745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009008040739538387,"score_gpt":0.2190784372292144,"score_spread":0.210070396489676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}