{"id":"W4409644169","doi":"10.1158/1538-7445.am2025-3280","title":"Abstract 3280: Type I IFN receptor signaling in myeloid and T cells drives antitumor immunity elicited by intratumoral delivery of immunogenic recombinant modified vaccinia virus Ankara","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Recombinant DNA; Virus; Myeloid cells; Immunity; Vaccinia; Virology; Immunology; Biology; Receptor; Immune system; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001620013,0.000378968,0.000269828,0.0001644648,0.000138645,0.0002652263,0.0002066231,0.0004071863,0.002654873],"category_scores_gemma":[0.00007685643,0.0001218393,0.0002290341,0.0001339253,0.0002538254,0.0001719177,0.0001974281,0.001142003,0.0008943702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004026055,"about_ca_system_score_gemma":0.000329624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004425322,"about_ca_topic_score_gemma":0.0005436767,"domain_scores_codex":[0.999795,0.00002913923,0.00002135713,0.00004462294,0.00005785204,0.00005215209],"domain_scores_gemma":[0.9999043,0.00001197033,0.000029925,0.00001105446,0.000008861307,0.000033938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001899139,0.00004182415,0.00005743225,0.00001967529,0.00000174339,0.0000218956,0.00001108074,0.00004230192,0.9986853,0.0001413431,0.00005940687,0.0007281449],"study_design_scores_gemma":[0.0001087772,0.0006868013,0.001797238,0.00000770907,0.00001401603,0.000165238,0.00001966359,0.001216133,0.9923338,0.00007693534,0.003569767,0.000003904186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928139,0.0006353798,0.002398522,0.0001989355,0.00005920959,0.00008467256,0.001105515,0.0001112384,0.002592589],"genre_scores_gemma":[0.9897856,0.0002937211,0.002851237,0.00009128649,0.00002188403,0.00008711731,0.0009474676,0.00003801535,0.00588369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002654873,"threshold_uncertainty_score":0.00888145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02870450054551363,"score_gpt":0.3501661769608879,"score_spread":0.3214616764153742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}