{"id":"W4409652571","doi":"10.1158/1538-7445.am2025-813","title":"Abstract 813: <i>In vitro</i> and <i>in vivo</i> modelling of drug tolerance and minimal residual disease to discover effective therapeutic combination strategies for EGFR-mutated lung cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Drug; Medicine; In vivo; Lung cancer; Disease; Cancer; In vitro; Pharmacology; Oncology; Cancer research; Internal medicine; Biology; Biotechnology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002234805,0.0003498012,0.0002398238,0.0001909448,0.0001171433,0.0004161962,0.0003113642,0.0003623632,0.00193233],"category_scores_gemma":[0.000119065,0.0001318164,0.0002697367,0.0001545696,0.0002035189,0.0002578738,0.0001868673,0.0005858282,0.0004941657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004859114,"about_ca_system_score_gemma":0.0002449866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002033286,"about_ca_topic_score_gemma":0.00155016,"domain_scores_codex":[0.9998814,0.00001809923,0.000007023,0.00002299895,0.00004575756,0.00002472365],"domain_scores_gemma":[0.9999263,0.00001227736,0.00002318392,0.000009117546,0.00001433046,0.00001478556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185504,0.0000838234,0.0003703659,0.00007451299,0.00000841849,0.00004910334,0.00001385441,0.007187226,0.9885803,0.0007155878,0.0002507122,0.002547503],"study_design_scores_gemma":[0.00003006456,0.001116578,0.001831039,0.00001508423,0.00002207076,0.0001627547,0.00003143397,0.04536351,0.9431126,0.0003355961,0.00796477,0.00001471646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9272481,0.003853607,0.05300418,0.0004231441,0.0001197388,0.0001741522,0.001681995,0.0004467324,0.01304824],"genre_scores_gemma":[0.9833651,0.001348849,0.009371202,0.0000623969,0.000008869388,0.0001061374,0.0008477484,0.00005368985,0.004835987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002033286,"threshold_uncertainty_score":0.006464243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03013187662450936,"score_gpt":0.4141105124048923,"score_spread":0.3839786357803829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}