{"id":"W4409652574","doi":"10.1158/1538-7445.am2025-5341","title":"Abstract 5341: Duration of CDK4/6 inhibitor (CDKi) treatment in metastatic HR+ HER2- breast cancer (mHRBC) is associated with changes in AKT pathway protein expression","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Metastatic breast cancer; Medicine; Breast cancer; Oncology; Protein kinase B; Cancer; Internal medicine; Cancer research; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513782,0.00007408203,0.0001817516,0.0002516343,0.000152361,0.0002462373,0.00008652596,0.0001453479,0.003037591],"category_scores_gemma":[0.0003085489,0.00007429647,0.0001428452,0.0003033471,0.0001243342,0.0001315189,0.0001227093,0.0001859662,0.000347808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668371,"about_ca_system_score_gemma":0.0001269745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008317358,"about_ca_topic_score_gemma":0.001159179,"domain_scores_codex":[0.9998966,0.00001231944,0.00000976724,0.00003113337,0.00002659114,0.00002350994],"domain_scores_gemma":[0.9997819,0.00004189404,0.0001047611,0.00001304053,0.00001845178,0.00003996284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01189718,0.000278285,0.7977254,0.0001718126,0.0001191514,0.0007740771,0.0001072595,0.0004043568,0.1406899,0.00009813863,0.001490278,0.04624419],"study_design_scores_gemma":[0.00003389932,0.0006168642,0.9888932,0.000004942343,0.00003791774,0.000973149,0.00003983618,0.0002057909,0.007922077,0.00002388493,0.001244881,0.000003489941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970015,0.000912095,0.0001177707,0.00003597336,0.000005921247,0.000006558212,0.0007874694,0.000009050721,0.001123655],"genre_scores_gemma":[0.9983979,0.0001342976,0.0001013486,0.00001803552,0.000006065723,0.000009474385,0.0007218227,0.000003254755,0.0006078014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003037591,"threshold_uncertainty_score":0.01016182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06060826507613826,"score_gpt":0.4004901628861432,"score_spread":0.3398818978100049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}