{"id":"W4409652574","doi":"10.1158/1538-7445.am2025-5341","title":"Abstract 5341: Duration of CDK4/6 inhibitor (CDKi) treatment in metastatic HR+ HER2- breast cancer (mHRBC) is associated with changes in AKT pathway protein expression","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Metastatic breast cancer; Medicine; Breast cancer; Oncology; Protein kinase B; Cancer; Internal medicine; Cancer research; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006030254,0.0002669221,0.000605081,0.000709132,0.00007878182,0.00002351175,0.0001442155,0.0001219414,0.0006047533],"category_scores_gemma":[0.00008827206,0.00019888,0.00005285388,0.001474397,0.0002237937,0.000180323,0.00005468154,0.0004639702,0.000003534924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002834162,"about_ca_system_score_gemma":0.001568798,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.007989992,"about_ca_topic_score_gemma":0.02427791,"domain_scores_codex":[0.9973665,0.0002278784,0.0004502091,0.0005407637,0.0007905025,0.0006240715],"domain_scores_gemma":[0.9986994,0.000157103,0.0001778651,0.0003802521,0.0004703018,0.000115056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005882645,0.001096248,0.03426978,0.0007703308,0.0002524398,0.0001426773,0.003457878,0.0001654799,0.8742103,0.00004266204,0.0001396687,0.07956986],"study_design_scores_gemma":[0.007541927,0.0005776873,0.1504053,0.007950994,0.00002745274,0.000004968829,0.001315864,0.00005954867,0.8305756,0.0002085546,0.001117713,0.0002143817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882073,0.002729676,0.00001737421,0.005999534,0.00006189665,0.002422926,0.0002579723,0.00003282067,0.0002705356],"genre_scores_gemma":[0.9937964,0.0003810632,0.0001094876,0.0001085832,0.00009127005,0.003640744,0.0000313184,0.00004652998,0.001794609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1161355,"threshold_uncertainty_score":0.9986159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06060826507613826,"score_gpt":0.4004901628861432,"score_spread":0.3398818978100049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}