{"id":"W4409653259","doi":"10.1093/discim/kyaf006","title":"CD28 and TCR differentially impact naïve and memory T cell responses","year":2025,"lang":"en","type":"article","venue":"Discovery Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis","keywords":"T-cell receptor; CD28; Psychology; Neuroscience; Cell biology; T cell; Biology; Chemistry; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000279352,0.0004085239,0.0006104243,0.0004261093,0.0004285459,0.0001051944,0.0003040509,0.0004811211,0.0002921517],"category_scores_gemma":[0.0001588538,0.0003365307,0.0001617962,0.0001955648,0.001036827,0.0003527717,0.0003500348,0.0005064426,0.0000778152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005788786,"about_ca_system_score_gemma":0.000231361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003013853,"about_ca_topic_score_gemma":0.00001597481,"domain_scores_codex":[0.9976567,0.0007440507,0.0004371022,0.0005202947,0.00003247301,0.0006093875],"domain_scores_gemma":[0.9984499,0.0007753226,0.0001440701,0.0005599321,0.00005291094,0.00001791895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006503589,0.0002012156,0.005150123,0.00003796626,0.0009052544,0.00001205694,0.0006197864,6.95737e-7,0.9696584,0.001879081,0.0009144819,0.01411735],"study_design_scores_gemma":[0.006375114,0.001128262,0.4691688,0.0001201,0.0001861499,0.0003135201,0.001668632,0.000002199073,0.4993445,0.001009693,0.02005493,0.0006280962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8990669,0.09686764,0.0001495177,0.0004063612,0.0009842728,0.0002871582,0.0000623803,0.0000837609,0.002092039],"genre_scores_gemma":[0.9576895,0.005055244,0.00001856681,0.0003613645,0.0000129736,0.00003595028,0.0000686194,0.00002702028,0.03673073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4703139,"threshold_uncertainty_score":0.9999087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006116174986822495,"score_gpt":0.249269764594236,"score_spread":0.2431535896074135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}