{"id":"W4409653259","doi":"10.1093/discim/kyaf006","title":"CD28 and TCR differentially impact naïve and memory T cell responses","year":2025,"lang":"en","type":"article","venue":"Discovery Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis","keywords":"T-cell receptor; CD28; Psychology; Neuroscience; Cell biology; T cell; Biology; Chemistry; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182893,0.0002857363,0.000301328,0.0001765184,0.00009589562,0.0004500163,0.000137336,0.0003602131,0.002230602],"category_scores_gemma":[0.0002619687,0.0001273637,0.0001392827,0.0001091315,0.0001916764,0.0002128573,0.0002644523,0.0006898455,0.0003586909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000149749,"about_ca_system_score_gemma":0.0001406949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001044189,"about_ca_topic_score_gemma":0.0001993315,"domain_scores_codex":[0.999575,0.0001080019,0.00003118831,0.00006505995,0.00008766528,0.0001330446],"domain_scores_gemma":[0.9997156,0.0001273904,0.00002753878,0.000023302,0.00002420059,0.00008195696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002842992,0.00005634336,0.0002024157,0.00002193173,0.000003697021,0.00001970326,0.00000547966,0.00003845293,0.9985192,0.00002470473,0.0000148497,0.0008089767],"study_design_scores_gemma":[0.0000394141,0.001430756,0.004543275,0.000006751632,0.00003795376,0.0002587823,0.00003998385,0.0007516401,0.9918615,0.00007830838,0.0009483213,0.000003353619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972795,0.001006537,0.0005622912,0.00003530356,0.00002817514,0.00001363009,0.00005923098,0.00001747955,0.0009979771],"genre_scores_gemma":[0.9977265,0.0002440923,0.0007702729,0.00005067604,0.00002132677,0.00001918309,0.00008788009,0.00001096112,0.001069142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002230602,"threshold_uncertainty_score":0.007462144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006116174986822495,"score_gpt":0.249269764594236,"score_spread":0.2431535896074135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}