{"id":"W4409665893","doi":"10.1097/iop.0000000000002941","title":"Identifying Minimum Single Dose of Recombinant Human Hyaluronidase for In Vitro Dissolution of Twenty-Two Hyaluronic Acid Fillers","year":2025,"lang":"en","type":"article","venue":"Ophthalmic Plastic and Reconstructive Surgery","topic":"Facial Rejuvenation and Surgery Techniques","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of British Columbia","funders":"","keywords":"Hyaluronidase; Hyaluronic acid; Medicine; Filler (materials); Dissolution; Mannitol; Surgery; Materials science; Biology; Biochemistry; Chemistry; Composite material; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002029198,0.0005436684,0.0007589437,0.0003497187,0.0002114408,0.0006422556,0.0004286238,0.0005342545,0.0008606103],"category_scores_gemma":[0.002768107,0.0003116808,0.0004710565,0.0003165066,0.0004803918,0.0004787747,0.0003783189,0.0004988653,0.0002881132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003265018,"about_ca_system_score_gemma":0.0005499607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005027937,"about_ca_topic_score_gemma":0.001049839,"domain_scores_codex":[0.9982663,0.0005361145,0.0003421842,0.0002812544,0.0004910377,0.00008321883],"domain_scores_gemma":[0.998114,0.0008249432,0.000372869,0.0002550305,0.0003372093,0.0000959743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005963145,0.0003159018,0.0008899948,0.0001316556,0.00001391022,0.00002959151,0.00006472776,0.000297067,0.9918163,0.00002384091,0.00003860831,0.00578197],"study_design_scores_gemma":[0.00004702399,0.00554941,0.00478016,0.00002925686,0.00005230229,0.0001351289,0.00004399421,0.001147433,0.9870927,0.00002235347,0.00108738,0.00001291455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763834,0.004247313,0.01704404,0.00008877802,0.00005450018,0.0006108643,0.0002624595,0.0001039061,0.001204654],"genre_scores_gemma":[0.9461488,0.001937448,0.04933263,0.00006025085,0.00003767742,0.0006525475,0.0006653569,0.00006092155,0.001104432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029198,"threshold_uncertainty_score":0.01073152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03225696274943134,"score_gpt":0.3083914992926689,"score_spread":0.2761345365432376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}