{"id":"W4409675561","doi":"10.1021/acsomega.5c00109","title":"Membrane-Active Peptides Derived from Natural Transmembrane Domains Function as Antibiotic Potentiators","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Potentiator; Transmembrane protein; Function (biology); Chemistry; Antibiotics; Membrane; Computational biology; Pharmacology; Biochemistry; Biology; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007482483,0.0003021077,0.0004196757,0.000182719,0.0004077706,0.00005327827,0.0002432112,0.0003103025,0.0001914505],"category_scores_gemma":[0.00004465791,0.0002727092,0.0002033805,0.0002415947,0.0003429684,0.0003335872,0.00007429116,0.000454029,0.0004667662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005600866,"about_ca_system_score_gemma":0.00008820761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132424,"about_ca_topic_score_gemma":0.0001692169,"domain_scores_codex":[0.9986383,0.0001300634,0.0002856315,0.0004617583,0.00004538722,0.000438887],"domain_scores_gemma":[0.9993178,0.0001930836,0.0001084831,0.000290275,0.00006642857,0.00002398929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006747501,0.0001136234,0.0004005042,0.00003165732,0.0007170029,0.00001007995,0.0003378285,0.000009325242,0.9898221,0.001164179,0.001589129,0.005129802],"study_design_scores_gemma":[0.001803808,0.0001123055,0.0237569,0.0001207705,0.0002572897,0.00001825474,0.001388407,0.000002798904,0.9634036,0.0006474026,0.008158891,0.0003295483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908856,0.001506464,0.000257311,0.0005609723,0.002140417,0.0002559155,0.00009545476,0.0001784461,0.004119481],"genre_scores_gemma":[0.9908162,0.0002225237,0.00006997183,0.001006674,0.00005984557,0.000005625182,0.0003852224,0.00002458238,0.007409396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0264185,"threshold_uncertainty_score":0.9999725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0055401300184883,"score_gpt":0.2138895097903559,"score_spread":0.2083493797718676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}