{"id":"W4409675561","doi":"10.1021/acsomega.5c00109","title":"Membrane-Active Peptides Derived from Natural Transmembrane Domains Function as Antibiotic Potentiators","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Potentiator; Transmembrane protein; Function (biology); Chemistry; Antibiotics; Membrane; Computational biology; Pharmacology; Biochemistry; Biology; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175342,0.0002866827,0.0001548508,0.0001299996,0.00008008449,0.00026606,0.000185782,0.0003526695,0.002031346],"category_scores_gemma":[0.0001790524,0.0001276319,0.0001456435,0.00007349631,0.0001793329,0.0003089808,0.000190006,0.0004709961,0.0005645875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001101898,"about_ca_system_score_gemma":0.00006980197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007761156,"about_ca_topic_score_gemma":0.0001228307,"domain_scores_codex":[0.9999107,0.00001782114,0.000006298239,0.00001904683,0.00002801147,0.00001814056],"domain_scores_gemma":[0.9998981,0.0000366282,0.00002490626,0.00000903818,0.00001333979,0.0000180336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004219173,0.000003908363,0.00002764306,0.00001237377,9.458889e-7,0.00001959037,0.000002573587,0.00002486721,0.9993944,0.00002728942,0.00002053131,0.0004236301],"study_design_scores_gemma":[0.000008840895,0.000115988,0.0008737104,0.000002554968,0.000002931239,0.000121586,0.000008255305,0.0006947751,0.9972071,0.00002526827,0.0009363605,0.000002604889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826536,0.001205071,0.01200878,0.0002273912,0.00004765733,0.0000484677,0.0003187133,0.0001831506,0.003307083],"genre_scores_gemma":[0.9779507,0.001135246,0.01642777,0.000161491,0.00001910785,0.00006776197,0.0005134678,0.00004393707,0.003680453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002031346,"threshold_uncertainty_score":0.006795585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0055401300184883,"score_gpt":0.2138895097903559,"score_spread":0.2083493797718676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}