{"id":"W4409676766","doi":"10.1200/jco-24-01606","title":"ADAGIO: A Phase IIb, Open-Label, Single-Arm, Multicenter Study Assessing the Efficacy and Safety of Adavosertib (AZD1775) as Treatment for Recurrent or Persistent Uterine Serous Carcinoma","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Regimen; Tolerability; Nausea; Neutropenia; Discontinuation; Clinical endpoint; Adverse effect; Anemia; Oncology; Chemotherapy regimen; Gastroenterology; Progression-free survival; Phases of clinical research; Chemotherapy; Surgery; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00229205,0.001111507,0.001589915,0.0004923414,0.0003139841,0.0009518988,0.0007367002,0.001151937,0.001630948],"category_scores_gemma":[0.000814995,0.0004538063,0.0008928695,0.0004736342,0.0009119804,0.0004913601,0.0003833996,0.001906757,0.0004284322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006036323,"about_ca_system_score_gemma":0.001351652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006103322,"about_ca_topic_score_gemma":0.002233614,"domain_scores_codex":[0.9994411,0.0003377665,0.00002540684,0.0000740738,0.000052659,0.00006896586],"domain_scores_gemma":[0.9995284,0.00007131204,0.000142442,0.00003363194,0.00002863524,0.0001956571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6801177,0.03680812,0.02143868,0.003120464,0.002287126,0.0003079461,0.0004689241,0.002147207,0.09738676,0.0005402979,0.008250959,0.1471259],"study_design_scores_gemma":[0.6823726,0.2709969,0.02692379,0.0001065849,0.001023485,0.0004638571,0.0001098924,0.001093777,0.006344954,0.0002528775,0.01026022,0.00005104275],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806406,0.009193645,0.0008045113,0.0006065923,0.000160028,0.004066425,0.002121015,0.0001669724,0.00224007],"genre_scores_gemma":[0.9827006,0.003669719,0.003225747,0.001487701,0.0002588362,0.004190195,0.002690298,0.00004431144,0.001732571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00229205,"threshold_uncertainty_score":0.01212168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3371098409690602,"score_gpt":0.5681743691901731,"score_spread":0.2310645282211128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}