{"id":"W4409680387","doi":"10.1093/brain/awaf019","title":"Disease-modifying effects of <i>TMEM106B</i> in genetic frontotemporal dementia: a longitudinal GENFI study","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Université Laval; Baycrest Hospital; University Health Network; Health Sciences Centre; Occupational Cancer Research Centre; Hospital for Sick Children; Montreal Neurological Institute and Hospital; Western University; University of Toronto; Sunnybrook Health Science Centre","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Alzheimer Nederland; Hjärnfonden; Vetenskapsrådet; Ministero della Salute; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; University of Toronto; University College London; Stichting Dioraphte; Sunnybrook Foundation; University of Cambridge; Department of Health and Social Care; Instituto de Salud Carlos III; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Alzheimer's Society; Wellcome Trust; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute","keywords":"C9orf72; Frontotemporal dementia; Frontotemporal lobar degeneration; Putamen; Atrophy; Psychology; Allele; Grey matter; Caudate nucleus; Dementia; Medicine; Oncology; Pathology; Internal medicine; Genetics; Disease; White matter; Biology; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001638298,0.0006538283,0.0005518093,0.0002328792,0.0005984985,0.0007977997,0.0006507492,0.0009989101,0.001054385],"category_scores_gemma":[0.001830939,0.0004223464,0.001614634,0.0004705787,0.0002885322,0.0003051848,0.0004228982,0.0009891678,0.0002001405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005012536,"about_ca_system_score_gemma":0.0004489554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01521621,"about_ca_topic_score_gemma":0.01641801,"domain_scores_codex":[0.9995373,0.000175172,0.00002396653,0.0001522079,0.00003494179,0.00007639111],"domain_scores_gemma":[0.9988285,0.0002152512,0.0003822614,0.0002422113,0.0001140702,0.0002177588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01339884,0.0005891554,0.9720728,0.000041432,0.002676701,0.0004535801,0.0003414348,0.000278089,0.003808363,0.00006210523,0.0006038054,0.005673782],"study_design_scores_gemma":[0.0001728403,0.0007673468,0.9970504,0.000007800256,0.0008755666,0.0001512587,0.0000522778,0.0003631906,0.00019665,0.00004646439,0.0003065679,0.00000961252],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990626,0.0002865586,0.00006422024,0.00005644644,0.000010909,0.000005696643,0.0003625409,0.000007454593,0.0001435881],"genre_scores_gemma":[0.9985562,0.0001116085,0.0001680247,0.00007108862,0.00001538402,0.00001941665,0.0006813806,0.000005751583,0.0003711905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01521621,"threshold_uncertainty_score":0.03025526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01736364906787275,"score_gpt":0.3282382939076459,"score_spread":0.3108746448397732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}