{"id":"W4409680387","doi":"10.1093/brain/awaf019","title":"Disease-modifying effects of <i>TMEM106B</i> in genetic frontotemporal dementia: a longitudinal GENFI study","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Université Laval; Baycrest Hospital; University Health Network; Health Sciences Centre; Occupational Cancer Research Centre; Hospital for Sick Children; Montreal Neurological Institute and Hospital; Western University; University of Toronto; Sunnybrook Health Science Centre","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Alzheimer Nederland; Hjärnfonden; Vetenskapsrådet; Ministero della Salute; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; University of Toronto; University College London; Stichting Dioraphte; Sunnybrook Foundation; University of Cambridge; Department of Health and Social Care; Instituto de Salud Carlos III; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Alzheimer's Society; Wellcome Trust; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute","keywords":"C9orf72; Frontotemporal dementia; Frontotemporal lobar degeneration; Putamen; Atrophy; Psychology; Allele; Grey matter; Caudate nucleus; Dementia; Medicine; Oncology; Pathology; Internal medicine; Genetics; Disease; White matter; Biology; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003008255,0.0001540544,0.0003774144,0.0002375253,0.00004480137,0.00001623234,0.000160939,0.00005616382,0.00006285479],"category_scores_gemma":[0.0003162767,0.0001324041,0.00008951506,0.0004337379,0.00007318098,0.00005259098,0.0001746767,0.0002057741,0.00001324864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201316,"about_ca_system_score_gemma":0.0001980532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006608549,"about_ca_topic_score_gemma":0.0001892332,"domain_scores_codex":[0.9982915,0.0001962292,0.0003627467,0.0003649517,0.0004302624,0.0003543343],"domain_scores_gemma":[0.9991744,0.0001663732,0.00005292238,0.0003951211,0.00005505712,0.0001561154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004044054,0.0009042058,0.9846133,0.0005270874,0.0001848821,0.0004587197,0.0002332581,0.00002436805,0.007447063,0.00003244343,0.0009264274,0.004243862],"study_design_scores_gemma":[0.004453692,0.0003818674,0.993534,0.0004011267,0.0001250706,0.000001633577,0.000052397,0.0004911399,0.0002032399,0.0001533241,0.0001089967,0.00009357063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941109,0.002248518,0.0004356544,0.001193006,0.00009301047,0.001545922,0.000002641593,0.00002894543,0.0003413403],"genre_scores_gemma":[0.9985904,0.00002517451,0.000382873,0.000228891,0.00004999238,0.0001219555,0.00000534542,0.00001711598,0.0005782481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008920664,"threshold_uncertainty_score":0.5399283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01736364906787275,"score_gpt":0.3282382939076459,"score_spread":0.3108746448397732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}