{"id":"W4409686990","doi":"10.1016/j.jtocrr.2025.100837","title":"Novel Approach to Proficiency Testing Reveals Significant Variations in Biomarker Practice Leading to Critical Differences in Lung Cancer Management","year":2025,"lang":"en","type":"article","venue":"JTO Clinical and Research Reports","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University Health Centre; Institut universitaire de cardiologie et de pneumologie de Québec; William Osler Health System; Queen Elizabeth II Health Sciences Centre; Ottawa Hospital; Centre Hospitalier de l’Université de Montréal","funders":"Pfizer Canada; Amgen Canada; AstraZeneca; Pfizer; Amgen","keywords":"Lung cancer; Biomarker; Medicine; Cancer; Oncology; Intensive care medicine; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02692957,0.0005179022,0.0002384626,0.001460855,0.001455414,0.002621886,0.001862139,0.0006712797,0.002002146],"category_scores_gemma":[0.06346044,0.0002832259,0.0003563282,0.00101594,0.001750443,0.000904155,0.002176539,0.0009331888,0.0005168378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005284639,"about_ca_system_score_gemma":0.00727293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03707102,"about_ca_topic_score_gemma":0.0486762,"domain_scores_codex":[0.9760982,0.01009721,0.001373787,0.003578698,0.007938934,0.0009131393],"domain_scores_gemma":[0.9237751,0.02616806,0.0168659,0.008014385,0.02346798,0.00170851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007825859,0.0005894859,0.7809745,0.0002987728,0.000227024,0.0008611049,0.02537502,0.002122606,0.01869646,0.003536969,0.007035621,0.1594999],"study_design_scores_gemma":[0.00007467446,0.001675939,0.8958459,0.0002217041,0.0001239283,0.00264059,0.0127403,0.02781722,0.03149299,0.00448078,0.02265435,0.0002315827],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457021,0.0002530014,0.0372016,0.002231072,0.0001186976,0.0007350576,0.0004337891,0.0004096405,0.01291512],"genre_scores_gemma":[0.9794222,0.00006697588,0.01846535,0.0004009184,0.00002839131,0.0002022001,0.0002215253,0.00003313846,0.001159397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03707102,"threshold_uncertainty_score":0.1424189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2473586770069443,"score_gpt":0.5728935209881609,"score_spread":0.3255348439812167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}