{"id":"W4409689367","doi":"10.1158/1538-7445.am2025-2837","title":"Abstract 2837: Mechanisms promoting chromosomal instability following the loss of p53 and Rb","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Cancer research; Genome instability; Chromosome instability; Instability; Chemistry; Biology; Cell biology; Genetics; Physics; DNA; DNA damage; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322967,0.0003207123,0.0002302827,0.0003195629,0.0001372869,0.0003278117,0.0002575657,0.0004152641,0.002137609],"category_scores_gemma":[0.0001085251,0.0001310369,0.0002193448,0.0001324212,0.0002635002,0.000239368,0.0002819927,0.0005566507,0.0008094029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199735,"about_ca_system_score_gemma":0.0001074512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000343652,"about_ca_topic_score_gemma":0.0002269676,"domain_scores_codex":[0.9998615,0.00001780603,0.00001517529,0.00002889876,0.00004307763,0.00003358602],"domain_scores_gemma":[0.999867,0.00001970485,0.00004876494,0.00002080622,0.0000104976,0.00003322247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005549631,0.000008927715,0.0001747219,0.00001692509,0.000002630795,0.000106468,0.000004184328,0.00002423703,0.9990205,0.0001009496,0.00002755025,0.0004573475],"study_design_scores_gemma":[0.00001150318,0.0001629851,0.006318248,0.00000600449,0.000008903961,0.0007161227,0.00002445086,0.0003542976,0.9903572,0.0001096193,0.001927541,0.000003215033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877771,0.004209893,0.003805954,0.000306555,0.00004487042,0.00003015602,0.0008228743,0.0002156472,0.002786968],"genre_scores_gemma":[0.9950044,0.000788814,0.000810353,0.00007175931,0.00001218664,0.00002835021,0.0004375697,0.00002091837,0.002825637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002137609,"threshold_uncertainty_score":0.007151008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04580659037959888,"score_gpt":0.3923078506116496,"score_spread":0.3465012602320507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}