{"id":"W4409690809","doi":"10.1158/1538-7445.am2025-73","title":"Abstract 73: Molecular characterization of senescence induced by PARPi in preclinical xenograft mouse models of ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Ovarian cancer; Cancer; Senescence; Cancer research; Medicine; Biology; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286021,0.000442111,0.0002656785,0.000725835,0.0001743647,0.0002689848,0.0001835389,0.0003661601,0.002684497],"category_scores_gemma":[0.0001060238,0.0001567652,0.0003663872,0.000356689,0.000174718,0.0002628787,0.0001189691,0.0007795198,0.0007016155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783508,"about_ca_system_score_gemma":0.0001773769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005440561,"about_ca_topic_score_gemma":0.0005842591,"domain_scores_codex":[0.99983,0.00001991833,0.00001874884,0.00003746245,0.00005057843,0.00004330273],"domain_scores_gemma":[0.9997941,0.00003217986,0.00005384695,0.00003333303,0.00003346776,0.00005302841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002604828,0.0001442383,0.0004722,0.00003899661,0.000007224869,0.00005063563,0.00002087684,0.00007595048,0.9970849,0.0001026057,0.0001370818,0.001604737],"study_design_scores_gemma":[0.00002994022,0.001260327,0.006646464,0.000007317336,0.00002173006,0.000276207,0.00002249453,0.0007947977,0.9876823,0.00004348212,0.003210592,0.000004329643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751493,0.002265106,0.0116913,0.00020803,0.00009259155,0.0002726519,0.005673892,0.0004882163,0.004158814],"genre_scores_gemma":[0.9658676,0.001947225,0.01025823,0.0001263725,0.00003755652,0.0005565582,0.008097704,0.0001183365,0.01299053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002684497,"threshold_uncertainty_score":0.008980572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1505554759126108,"score_gpt":0.4820722729312489,"score_spread":0.3315167970186381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}