{"id":"W4409691001","doi":"10.1158/1538-7445.am2025-523","title":"Abstract 523: Minnelide as a potential treatment strategy for CIC::DUX4 sarcoma","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Sarcoma; Internal medicine; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009128205,0.0003783213,0.0003322807,0.0002577561,0.000118065,0.0002484823,0.0002169415,0.0003448889,0.003907298],"category_scores_gemma":[0.00006221515,0.00008254768,0.0002387242,0.0001613334,0.0001337752,0.0002241647,0.0001845516,0.0004553854,0.000607854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003127076,"about_ca_system_score_gemma":0.0002627468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004911958,"about_ca_topic_score_gemma":0.0009611213,"domain_scores_codex":[0.999964,0.000005487861,0.000003326433,0.000008086744,0.000008119247,0.00001092929],"domain_scores_gemma":[0.9999747,0.000003090911,0.000006591573,0.000002375591,0.000004683536,0.000008636162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002149206,0.000428821,0.0006923719,0.0005499031,0.00003961097,0.0004508849,0.00003920329,0.000904453,0.9461127,0.0004947853,0.001797015,0.04634109],"study_design_scores_gemma":[0.0009293471,0.009861147,0.005971029,0.00007490026,0.000150483,0.001853152,0.00005794388,0.001418524,0.9428914,0.0002253511,0.03654132,0.00002535602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688395,0.01486795,0.002730618,0.0006663881,0.0002003345,0.0004150726,0.001968346,0.0002030804,0.01010853],"genre_scores_gemma":[0.978177,0.007920331,0.003383327,0.0003809093,0.00005701999,0.0001401182,0.002165171,0.00003287311,0.007743271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003907298,"threshold_uncertainty_score":0.01307118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06243188665912073,"score_gpt":0.431297120002055,"score_spread":0.3688652333429343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}