{"id":"W4409691404","doi":"10.1158/1538-7445.am2025-326","title":"Abstract 326: Chemotherapies change the NRF2 levels and impact the differentiation and growth of human high grade serous ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Serous ovarian cancer; Serous fluid; Ovarian cancer; Cancer; Oncology; Medicine; Internal medicine; Gynecology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005872988,0.0001958203,0.0001577907,0.0001626484,0.0001145229,0.0001393998,0.00007425751,0.0001691572,0.002947616],"category_scores_gemma":[0.00005424393,0.00007395737,0.0002052111,0.0001906006,0.00009273453,0.0001116847,0.00009312551,0.000280802,0.0004035044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001326444,"about_ca_system_score_gemma":0.00008715857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008303232,"about_ca_topic_score_gemma":0.0008074401,"domain_scores_codex":[0.9999375,0.000008322974,0.000008987326,0.00001452141,0.0000163091,0.0000143213],"domain_scores_gemma":[0.9999709,0.000005934625,0.000005868395,0.000004789068,0.000005937671,0.000006584065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002773546,0.00006605854,0.000617491,0.00005909637,0.00000798132,0.00004391795,0.00001364439,0.00004251792,0.9972044,0.00002831783,0.0001656196,0.001473652],"study_design_scores_gemma":[0.00003468598,0.0005866736,0.01020377,0.000005134472,0.0000253604,0.0002871246,0.00003794621,0.0003744139,0.9851121,0.00002248509,0.003306943,0.000003338701],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944137,0.001668124,0.000723621,0.0001226406,0.00004656822,0.00002941926,0.001374305,0.00004758171,0.001573867],"genre_scores_gemma":[0.9911295,0.0008137319,0.0009329068,0.0000791967,0.000008855744,0.00005008229,0.002504269,0.00001174525,0.004469718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002947616,"threshold_uncertainty_score":0.009860814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07178215362659095,"score_gpt":0.3896085126971334,"score_spread":0.3178263590705424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}