{"id":"W4409691643","doi":"10.1158/1538-7445.am2025-581","title":"Abstract 581: Better together: Biparatopic [225Ac]Ac-labeled anti-HER2 antibody-drug radioconjugates using two domain-specific antibodies for the treatment of trastuzumab and T-DM1 resistant HER2-positive breast cancer xenografts","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Université Laval","funders":"","keywords":"Trastuzumab; Medicine; Antibody; Cancer; Drug; Trastuzumab emtansine; Breast cancer; Pharmacology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201798,0.0003612958,0.0002711668,0.0002040081,0.0001323427,0.0002805031,0.0002586004,0.0003752477,0.004065293],"category_scores_gemma":[0.00009916038,0.0001215432,0.0002163239,0.0001716049,0.0001230385,0.0002993628,0.0001672566,0.0003749096,0.001444457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328476,"about_ca_system_score_gemma":0.000228481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007082249,"about_ca_topic_score_gemma":0.0007255193,"domain_scores_codex":[0.9998697,0.00001276427,0.000008034602,0.00003940231,0.00004971512,0.00002044831],"domain_scores_gemma":[0.9999596,0.000003191157,0.00001169316,0.000004100193,0.00001019013,0.00001134619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003191858,0.0001137943,0.0002343995,0.00007636657,0.00001314608,0.00003987016,0.0000154178,0.0003381664,0.9913068,0.000146084,0.0004524364,0.006944239],"study_design_scores_gemma":[0.0000529187,0.0007717412,0.001246831,0.000004231996,0.00003190352,0.0001594295,0.000007884183,0.001104875,0.9896554,0.00002807143,0.006929795,0.000006981275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788033,0.003442426,0.008827794,0.0003441376,0.0001315632,0.0001285751,0.0004672807,0.0003063026,0.007548577],"genre_scores_gemma":[0.9709401,0.001469598,0.008774686,0.0002404005,0.00003721672,0.00006762685,0.0009658227,0.0001044318,0.01740006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004065293,"threshold_uncertainty_score":0.01359981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07219079361530506,"score_gpt":0.4560424873402374,"score_spread":0.3838516937249323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}