{"id":"W4409696327","doi":"10.1038/d41586-025-01152-6","title":"Clinical trials by the numbers","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"World Federation of Science Journalists","funders":"","keywords":"Clinical trial; Medicine; Computational biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004960637,0.0007882903,0.001551619,0.001003337,0.001005919,0.005124896,0.000852812,0.003867643,0.1947056],"category_scores_gemma":[0.0141095,0.0006487568,0.0008615797,0.0009202075,0.001141259,0.001850912,0.001375434,0.007334445,0.1436817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001533223,"about_ca_system_score_gemma":0.003124808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009524885,"about_ca_topic_score_gemma":0.002338086,"domain_scores_codex":[0.995787,0.001783914,0.0002611532,0.0006631223,0.001221682,0.0002831054],"domain_scores_gemma":[0.9920253,0.001807343,0.0006226973,0.001023793,0.001587918,0.002932952],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001592414,0.0001240852,0.0005205679,0.0002556747,0.00005440183,0.00004352486,0.00002226054,0.0001613242,0.001316909,0.01556981,0.8450828,0.1352563],"study_design_scores_gemma":[0.000961179,0.0001511877,0.0005794073,0.0001833458,0.00001866211,0.00006778274,0.00001453105,0.0002822001,0.0003618711,0.003492266,0.9938698,0.00001773007],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.003069982,0.03407118,0.008693643,0.1268126,0.09137496,0.002370252,0.007920915,0.001022717,0.7246638],"genre_scores_gemma":[0.02531485,0.01711476,0.01343409,0.06442898,0.02360249,0.004191472,0.005247143,0.0005915868,0.8460748],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9950393,"threshold_uncertainty_score":0.6513551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767226757905643,"score_gpt":0.3912157707739339,"score_spread":0.3735435031948775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}