{"id":"W4409698226","doi":"10.1128/mbio.03816-24","title":"Ex vivo and in vivo HIV-1 latency reversal by “Mukungulu,” a protein kinase C-activating African medicinal plant extract","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Center for AIDS Research, University of Washington; Fondations communautaires du Canada; National Institutes of Health; Fondation Rideau Hall; Instituto Nacional de Cancerología; Alliance for Accelerating Excellence in Science in Africa; W. W. Smith Charitable Trust; African Academy of Sciences; Canadian Institutes of Health Research; Philadelphia Foundation; Wellcome Trust; University of Pennsylvania; New Partnership for Africa's Development","keywords":"Ex vivo; Peripheral blood mononuclear cell; In vivo; Medicine; Pharmacology; Human immunodeficiency virus (HIV); Immunology; Virology; Traditional medicine; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255458,0.0003128791,0.0001147249,0.0001174767,0.00006908197,0.0001272289,0.0001459722,0.000178229,0.00129309],"category_scores_gemma":[0.00006453932,0.00006898151,0.0001946457,0.00007413963,0.0001393409,0.0001467353,0.00007118261,0.0004827515,0.0002849754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009768381,"about_ca_system_score_gemma":0.00009567649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002964654,"about_ca_topic_score_gemma":0.0003790635,"domain_scores_codex":[0.9999405,0.00001505506,0.00000512121,0.000008582148,0.000008489228,0.00002225681],"domain_scores_gemma":[0.9999489,0.00001470826,0.00001220784,0.000008389628,0.000004873618,0.00001095408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003275975,0.00009581802,0.0000729048,0.00003662945,0.000003506212,0.00001377686,0.000006296812,0.00004464336,0.9984341,0.0000341271,0.00003010675,0.0009005882],"study_design_scores_gemma":[0.0000230733,0.001764026,0.0008919302,0.000003418177,0.000009141804,0.00005733825,0.000009125967,0.0001787409,0.9965022,0.00001283765,0.0005468567,0.000001330503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995092,0.0009036529,0.001740751,0.00009237819,0.00003129595,0.00004678969,0.0003565762,0.00006869176,0.001667855],"genre_scores_gemma":[0.9952011,0.0005294861,0.001641511,0.00005437858,0.00001148352,0.0000387828,0.0006120056,0.00001432856,0.001896891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129309,"threshold_uncertainty_score":0.004325807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007854364308642309,"score_gpt":0.2374561036170433,"score_spread":0.229601739308401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}