{"id":"W4409711008","doi":"10.1093/rheumatology/keaf193","title":"Diminished SUV3 expression and its functional implications in the IFN-enriched monocyte subset of childhood Sjögren’s disease","year":2025,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kootenay Association for Science & Technology","funders":"National Institute of Dental and Craniofacial Research; National Institutes of Health; Sjögren's Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Research Foundation of Korea; Ministry of Higher Education and Scientific Research","keywords":"Gene knockdown; Protein kinase R; Innate immune system; Cell biology; RNA silencing; Biology; Phagocytosis; CD14; Proinflammatory cytokine; Molecular biology; Mitochondrion; Intracellular; RNA; Interferon; RNA interference; Chemistry; Immune system; Kinase; Protein kinase A; Inflammation; Biochemistry; Immunology; Apoptosis; Gene; Flow cytometry; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144996,0.0001011069,0.0001665227,0.0001178462,0.0001057931,0.00001402205,0.00007680129,0.00005541301,0.00007425504],"category_scores_gemma":[0.0001451499,0.00006944861,0.00006247996,0.0003156718,0.00003504541,0.00006799516,0.00004211326,0.0001272972,0.000004749722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001456191,"about_ca_system_score_gemma":0.0001072405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002527727,"about_ca_topic_score_gemma":0.00001749266,"domain_scores_codex":[0.9992819,0.00004519465,0.0002056378,0.0002058137,0.000127636,0.0001338417],"domain_scores_gemma":[0.9993822,0.0001491791,0.00004575213,0.0002970393,0.00005172149,0.00007412172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001001339,0.002359096,0.9493563,0.0001558204,0.0001110589,0.00001220139,0.001345687,0.00004942231,0.005431306,0.01669017,0.0212058,0.002281841],"study_design_scores_gemma":[0.00180336,0.00005904124,0.9930871,0.00005673028,0.0001027994,0.000005088883,0.0003227199,0.0001639232,0.00008432821,0.001828544,0.002420834,0.00006555921],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859821,0.002458449,0.0003437142,0.006752491,0.0001124348,0.0004843911,0.00006682808,0.00003074676,0.003768889],"genre_scores_gemma":[0.9979649,0.0002176589,0.0000477742,0.000922001,0.00005967934,0.0001231963,0.0001939892,0.000007071696,0.0004637196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04373082,"threshold_uncertainty_score":0.2832032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205676266708436,"score_gpt":0.2706239974052425,"score_spread":0.2500563707343989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}