{"id":"W4409711008","doi":"10.1093/rheumatology/keaf193","title":"Diminished SUV3 expression and its functional implications in the IFN-enriched monocyte subset of childhood Sjögren’s disease","year":2025,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kootenay Association for Science & Technology","funders":"National Institute of Dental and Craniofacial Research; National Institutes of Health; Sjögren's Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Research Foundation of Korea; Ministry of Higher Education and Scientific Research","keywords":"Gene knockdown; Protein kinase R; Innate immune system; Cell biology; RNA silencing; Biology; Phagocytosis; CD14; Proinflammatory cytokine; Molecular biology; Mitochondrion; Intracellular; RNA; Interferon; RNA interference; Chemistry; Immune system; Kinase; Protein kinase A; Inflammation; Biochemistry; Immunology; Apoptosis; Gene; Flow cytometry; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072835,0.0002208682,0.0002056722,0.0002488778,0.0001771511,0.0002578925,0.00009347061,0.000239345,0.001055468],"category_scores_gemma":[0.0001355854,0.00008300551,0.0001559105,0.0001791658,0.000163519,0.00009967032,0.0001654712,0.0002138044,0.0001951995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721498,"about_ca_system_score_gemma":0.0001145935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006811088,"about_ca_topic_score_gemma":0.0009674573,"domain_scores_codex":[0.9998697,0.00001694869,0.00001835515,0.00002901907,0.00002955493,0.00003641262],"domain_scores_gemma":[0.9999115,0.00001138241,0.00003604129,0.00000692132,0.00001238924,0.00002177081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001187786,0.00003004264,0.05012274,0.0001064609,0.00002248271,0.001751343,0.0001731077,0.00007445516,0.9417502,0.00007632476,0.00008901391,0.004616145],"study_design_scores_gemma":[0.00005184095,0.0007791402,0.7421854,0.00004501246,0.0001055474,0.01262514,0.000766053,0.0008279253,0.239575,0.000139364,0.002885464,0.00001407937],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990145,0.0005020101,0.000170643,0.00001643132,0.000003531607,0.00000389195,0.000161881,0.000005463306,0.0001216193],"genre_scores_gemma":[0.9990539,0.0001892303,0.0002618768,0.00001508006,0.000004274619,0.000006153626,0.0002243538,0.000002836309,0.0002422595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055468,"threshold_uncertainty_score":0.00353092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205676266708436,"score_gpt":0.2706239974052425,"score_spread":0.2500563707343989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}