{"id":"W4409713352","doi":"10.1002/ijc.35448","title":"Real‐world comparative effectiveness and safety of Pertuzumab in patients with HER2+ metastatic breast cancer: A pan‐Canadian population‐based cohort study","year":2025,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Sunnybrook Health Science Centre; McGill University; Simon Fraser University; Hospital for Sick Children; University of Saskatchewan; University of New Brunswick; Dalhousie University; Newfoundland and Labrador Centre for Applied Health Research; OmniActive Health Technologies (Canada); University of Manitoba; Government of Manitoba; Centre for Addiction and Mental Health; University of Calgary; Health Sciences Centre; CancerCare Manitoba; Saskatchewan Cancer Agency; Canadian Centre for Applied Research in Cancer Control; University of Toronto; Public Health Ontario","funders":"Canadian Institutes of Health Research","keywords":"Pertuzumab; Medicine; Internal medicine; Propensity score matching; Febrile neutropenia; Metastatic breast cancer; Trastuzumab; Population; Breast cancer; Incidence (geometry); Cumulative incidence; Cohort; Cancer; Chemotherapy; Oncology; Surgery; Neutropenia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005215222,0.0007013705,0.001266595,0.001198167,0.001162391,0.001316572,0.001413002,0.0008497657,0.001327215],"category_scores_gemma":[0.01153766,0.0004185803,0.002933504,0.004193418,0.000750702,0.0003515886,0.0006538318,0.0008976874,0.0001087982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01774876,"about_ca_system_score_gemma":0.01758913,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8905742,"about_ca_topic_score_gemma":0.8966865,"domain_scores_codex":[0.9959962,0.001206192,0.0004061531,0.0006365933,0.00125498,0.000499827],"domain_scores_gemma":[0.9907101,0.001637592,0.003068997,0.0007218137,0.002994078,0.0008673469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007803785,0.0002248931,0.9469468,0.001477885,0.02149781,0.0002062027,0.000443633,0.001368378,0.0003557658,0.0004271071,0.002519318,0.01672839],"study_design_scores_gemma":[0.001944482,0.0008697369,0.9796069,0.0003007974,0.01078042,0.0002315521,0.000297233,0.00181574,0.0001366336,0.000178682,0.003747082,0.00009086714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726972,0.01591146,0.0003568679,0.0005661967,0.00004407447,0.0002603062,0.00877302,0.00001633098,0.001374563],"genre_scores_gemma":[0.9937741,0.002261536,0.0004116834,0.0002428623,0.00003280812,0.00007909995,0.003027348,0.000005650299,0.0001650395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1094258,"threshold_uncertainty_score":0.2201404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075718482011779,"score_gpt":0.4055644816163519,"score_spread":0.3848072967962341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}