{"id":"W4409713790","doi":"10.1016/j.joca.2025.02.578","title":"GUT MICROBIOME DYSBIOSIS IS ASSOCIATED WITH OSTEOARTHRITIS BY ALTERING GLYCINE, SERINE, AND THREONINE METABOLISM PATHWAY","year":2025,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Dysbiosis; Serine; Microbiome; Threonine; Glycine; Osteoarthritis; Metabolism; Chemistry; Medicine; Biochemistry; Biology; Bioinformatics; Amino acid; Pathology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176712,0.0003872693,0.0004372771,0.0004127072,0.0002384078,0.000522989,0.0001507595,0.0003743985,0.001559289],"category_scores_gemma":[0.0003594795,0.0002574727,0.0004458225,0.0004352439,0.0002171333,0.0001959295,0.0003684554,0.0005378431,0.000186957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001875542,"about_ca_system_score_gemma":0.0002881462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002012816,"about_ca_topic_score_gemma":0.00269714,"domain_scores_codex":[0.9998055,0.00004117178,0.00001873647,0.00005179245,0.00003665584,0.00004617094],"domain_scores_gemma":[0.9997126,0.00001890863,0.0001675123,0.00001339553,0.0000298186,0.00005763895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008111686,0.0002946376,0.2018979,0.0006152912,0.001144122,0.001163571,0.000209133,0.0002633413,0.7620195,0.0005256846,0.0007841781,0.02297096],"study_design_scores_gemma":[0.00008957888,0.0004905275,0.9676778,0.00007892284,0.0005521767,0.001195458,0.0003003656,0.001040519,0.02617524,0.0005548557,0.001808302,0.00003630331],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917795,0.005812069,0.001041074,0.0001956161,0.00005051108,0.000009322134,0.0004606736,0.00003324009,0.0006179551],"genre_scores_gemma":[0.9965106,0.001462241,0.0007835802,0.00009566043,0.00001866168,0.00001155661,0.0003083625,0.00001153538,0.0007978681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002012816,"threshold_uncertainty_score":0.00521636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003154798978458441,"score_gpt":0.2027373857887863,"score_spread":0.1995825868103278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}