{"id":"W4409715710","doi":"10.1016/j.joca.2025.02.069","title":"Identification of Epigenetic Markers associated with Recovery from Pain Following Surgical Intervention for Lumbar Spinal Stenosis due to Spine Osteoarthritis","year":2025,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Krembil Foundation; Arthritis Society; McGill University; University Health Network","funders":"","keywords":"Medicine; Osteoarthritis; Spinal stenosis; Lumbar spinal stenosis; Back pain; Intervention (counseling); Identification (biology); Lumbar; Physical therapy; Physical medicine and rehabilitation; Surgery; Pathology; Biology; Psychiatry; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272738,0.0001067199,0.0002250217,0.0004145644,0.0001540249,0.0002461484,0.0001329822,0.0002062714,0.0009717168],"category_scores_gemma":[0.0006283335,0.00008443774,0.0001655572,0.0003740962,0.0001504285,0.00008972407,0.0001361718,0.000220138,0.00009942256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001348437,"about_ca_system_score_gemma":0.0001384043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009485851,"about_ca_topic_score_gemma":0.002170371,"domain_scores_codex":[0.9999099,0.00001394783,0.000007555085,0.00002106848,0.00002271415,0.00002476964],"domain_scores_gemma":[0.9996973,0.00005207086,0.0001740653,0.000009705974,0.00003658335,0.00003019321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003949961,0.0004326256,0.6949096,0.0002252237,0.0003701417,0.0006881717,0.0003582447,0.000190591,0.2532422,0.0001680303,0.0003023042,0.04516292],"study_design_scores_gemma":[0.00001097974,0.0002672624,0.9949129,0.000007142517,0.00006006145,0.00024179,0.0001121723,0.0001717413,0.003955629,0.00003620675,0.0002200761,0.000003972517],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985375,0.0007611319,0.0002613207,0.00004217715,0.000007168142,0.000005668629,0.0001074247,0.000004132271,0.0002734525],"genre_scores_gemma":[0.9988667,0.0002584207,0.0002289688,0.00003260576,0.000008648175,0.000007472155,0.0001474384,0.000001787432,0.0004480141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009717168,"threshold_uncertainty_score":0.003250659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005464067554763349,"score_gpt":0.2507635874667042,"score_spread":0.2452995199119408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}