{"id":"W4409717171","doi":"10.1016/j.jbc.2025.108524","title":"A cobalamin-dependent pathway of choline demethylation from the human gut acetogen Eubacterium limosum","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; U.S. Department of Energy","keywords":"Eubacterium; Cobalamin; Demethylation; Chemistry; Corrinoid; Biochemistry; Microbiology; Food science; Biology; Methylation; Bacteria; Vitamin B12; Methyltransferase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009039315,0.0004021861,0.0002686726,0.0001934111,0.0002040863,0.0002285137,0.000146569,0.0003338744,0.0004295973],"category_scores_gemma":[0.0002151391,0.0001376167,0.0003189362,0.0001796842,0.0001129468,0.000204534,0.0003529582,0.0002725558,0.0004114704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206279,"about_ca_system_score_gemma":0.000265843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001784532,"about_ca_topic_score_gemma":0.001380653,"domain_scores_codex":[0.9999076,0.00001514734,0.000009392038,0.00002784529,0.00002014804,0.00001983369],"domain_scores_gemma":[0.9999216,0.000009887446,0.00001539407,0.00001294009,0.00002345666,0.00001673799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229803,0.000007031178,0.001059017,0.00009244448,0.000006814904,0.0001516933,0.00002689908,0.00003102881,0.9957082,0.00004760491,0.00004254257,0.002703807],"study_design_scores_gemma":[0.00001888036,0.0001887335,0.02399619,0.00002427535,0.00004451633,0.001411478,0.0001636177,0.001326784,0.9683869,0.0001204849,0.004302735,0.00001539936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982109,0.005441755,0.008974086,0.0004541861,0.00005843994,0.00006048335,0.001498528,0.0001636847,0.001240014],"genre_scores_gemma":[0.9807098,0.001623632,0.01285838,0.0001114847,0.00001374425,0.00003184921,0.002139932,0.00002504551,0.002486068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784532,"threshold_uncertainty_score":0.003548205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04254092969598354,"score_gpt":0.3297720415663967,"score_spread":0.2872311118704131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}