{"id":"W4409721270","doi":"10.1200/po-24-00500","title":"Larotrectinib Compared With Real-World Non–Tropomyosin Receptor Kinase Inhibitor Therapies in Patients With Tropomyosin Receptor Kinase Fusion Cancer","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thermo Fisher Scientific (Canada); Bayer (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Internal medicine; Trk receptor; Oncology; Cancer; Hazard ratio; Progression-free survival; Lung cancer; Receptor; Confidence interval; Neurotrophin; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001898356,0.0004320369,0.0009065876,0.0006850162,0.0002553697,0.00004139019,0.0001700206,0.0002306733,0.001058754],"category_scores_gemma":[0.00006177688,0.0002868549,0.00009567926,0.001212684,0.0002040958,0.0001877384,0.00009057676,0.0004393503,0.00004929889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002219636,"about_ca_system_score_gemma":0.001213417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003258975,"about_ca_topic_score_gemma":0.008631778,"domain_scores_codex":[0.9973257,0.0002533541,0.0006426108,0.000793839,0.000467597,0.0005168805],"domain_scores_gemma":[0.9981437,0.0003009259,0.0003036244,0.0005540168,0.0004777482,0.0002199511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02848551,0.005750431,0.7220641,0.0001183261,0.0006037072,0.00007073635,0.003318912,0.0001102401,0.005534964,0.00022398,0.04580433,0.1879148],"study_design_scores_gemma":[0.03712828,0.006445922,0.6524257,0.002093118,0.0004779022,0.000002854607,0.001053391,0.00005838441,0.006254931,0.0000596176,0.293499,0.0005008923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984308,0.0004220115,0.0001010554,0.004061772,0.0009373684,0.002740699,0.0001142105,0.0001136045,0.007201297],"genre_scores_gemma":[0.9775199,0.0004833701,0.008148278,0.0009982008,0.0002399305,0.001055919,0.0004459905,0.00007734208,0.01103104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2476947,"threshold_uncertainty_score":0.9999583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139844470296533,"score_gpt":0.3433478454091123,"score_spread":0.331949400706147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}