{"id":"W4409726683","doi":"10.1101/2025.04.22.649001","title":"Contributions of β-lactamase substrate specificity and outer membrane permeability to the antibiotic sheltering of β-lactam-susceptible bacteria","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Queen's University","funders":"","keywords":"Lactam; Bacteria; Antibiotics; Bacterial outer membrane; Microbiology; Substrate specificity; Permeability (electromagnetism); Chemistry; Substrate (aquarium); Membrane; Biophysics; Biology; Biochemistry; Stereochemistry; Enzyme; Ecology; Genetics; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006284464,0.0005497403,0.0005119023,0.000356784,0.0002310205,0.00135508,0.0002770199,0.0005403249,0.0007133401],"category_scores_gemma":[0.001295023,0.0002909093,0.0002884293,0.0002430231,0.0005174433,0.0006057572,0.0004435259,0.001001554,0.0004554535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003443315,"about_ca_system_score_gemma":0.0002828856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000540141,"about_ca_topic_score_gemma":0.0004640814,"domain_scores_codex":[0.9994758,0.0001224031,0.00003550124,0.0001067912,0.0001931632,0.00006637351],"domain_scores_gemma":[0.9994587,0.0002356496,0.0001157735,0.00005951687,0.00007061949,0.00005961191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009058063,0.00002751757,0.00135921,0.00006383904,0.000008638455,0.00004775836,0.00003780884,0.0001775034,0.995201,0.0002568244,0.00005459443,0.002674554],"study_design_scores_gemma":[0.000004980596,0.00003985923,0.005650447,0.000006314885,0.000009094771,0.0001226103,0.0000415759,0.002638498,0.990537,0.000225853,0.0007145194,0.000009331977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721527,0.004035873,0.02013003,0.0004009793,0.00006045622,0.00003322599,0.0003513968,0.0001640186,0.002671347],"genre_scores_gemma":[0.988773,0.001186803,0.00771471,0.00008356164,0.00001939315,0.00003079607,0.000261131,0.00006210888,0.001868387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135508,"threshold_uncertainty_score":0.003323555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005357036932487,"score_gpt":0.2355473326124017,"score_spread":0.2254937622430768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}