{"id":"W4409726959","doi":"10.17504/protocols.io.14egn6zjql5d/v2","title":"Fluorescence assay for Enterovirus A71 3C protease activity measurement for screening against antiviral molecules v2","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Virology; Fluorescence; Protease; Enterovirus; Enterovirus 71; Chemistry; Biology; Biochemistry; Virus; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008622219,0.001513728,0.0009550278,0.001024531,0.000487587,0.0005446338,0.0007172802,0.001044721,0.006770733],"category_scores_gemma":[0.0005916091,0.0004232357,0.0007495939,0.0006929464,0.0002482291,0.0004198998,0.0005035561,0.001585973,0.005209608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004442959,"about_ca_system_score_gemma":0.0003190861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003721898,"about_ca_topic_score_gemma":0.0004490011,"domain_scores_codex":[0.9988089,0.0002829009,0.00008795671,0.0002232731,0.0004479108,0.0001490388],"domain_scores_gemma":[0.9996538,0.00008179589,0.00003408969,0.00006245539,0.0001281126,0.00003976674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023425,0.00008914418,0.0001688426,0.0001664861,0.00001443999,0.00004031462,0.0000375124,0.0001389324,0.9928398,0.0003164393,0.0007153533,0.005370238],"study_design_scores_gemma":[0.00001544283,0.0003941751,0.001016212,0.00003832749,0.00002749145,0.000312724,0.00002051014,0.001012045,0.9857562,0.0001613338,0.01122317,0.00002243307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3699153,0.01175882,0.5679393,0.0006298585,0.0007147368,0.003397957,0.00889638,0.004876185,0.03187136],"genre_scores_gemma":[0.4170581,0.0113331,0.465169,0.0003705562,0.0001766389,0.006601908,0.02721999,0.0008691503,0.07120146],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006770733,"threshold_uncertainty_score":0.02265036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1008549280105265,"score_gpt":0.3637299783967682,"score_spread":0.2628750503862417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}