{"id":"W4409727592","doi":"10.1101/2025.04.19.649632","title":"Huib32: A Potent and Selective USP32 Inhibitor Modulating Endosomal Processes and Advancing Cell-Permeable USP32 Probes","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Chinese Academy of Medical Sciences; Pfizer","keywords":"Endosome; Chemistry; Cell biology; Cell; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902995,0.0004299456,0.0001916086,0.0001938906,0.0001180912,0.0002124325,0.0002780718,0.0003915867,0.001049103],"category_scores_gemma":[0.0000971581,0.0001672824,0.0001408337,0.0001348073,0.0002515592,0.0001963473,0.000204482,0.0004565452,0.0003976628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003213887,"about_ca_system_score_gemma":0.0001849896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005573286,"about_ca_topic_score_gemma":0.0004051678,"domain_scores_codex":[0.9999064,0.00001906694,0.000004948259,0.00002272503,0.00002535799,0.00002136345],"domain_scores_gemma":[0.9999596,0.000007686659,0.00001112169,0.000004544494,0.000005711804,0.00001133588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005176147,0.00001659562,0.0000492723,0.00002589406,0.000002501987,0.00004017371,0.00000588723,0.0000975572,0.9974157,0.0003435842,0.0001328234,0.001818314],"study_design_scores_gemma":[0.000005163208,0.00003135548,0.00009228738,8.333932e-7,0.000001665368,0.00005844248,0.000001225147,0.0003093636,0.998235,0.00001824528,0.001244936,0.000001525904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.934917,0.005586377,0.04815889,0.0004501439,0.0001076442,0.0001530716,0.0007805375,0.000656357,0.00919003],"genre_scores_gemma":[0.9568478,0.002206821,0.03163422,0.0001955623,0.00003163852,0.0001081169,0.000623705,0.00005903518,0.008293096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049103,"threshold_uncertainty_score":0.003509581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00728228150867774,"score_gpt":0.2067827202714257,"score_spread":0.1995004387627479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}