{"id":"W4409728494","doi":"10.1101/2025.04.10.648241","title":"A Spray Dried Replicon Vaccine Platform for Pandemic Response","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Biomedical Advanced Research and Development Authority; U.S. Department of Health and Human Services","keywords":"Replicon; Pandemic; Virology; Coronavirus disease 2019 (COVID-19); Medicine; Biology; Internal medicine; Genome; Genetics; Infectious disease (medical specialty); Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001593071,0.0002826901,0.0001971901,0.0001301586,0.00008537117,0.0001532229,0.0002256129,0.0003384442,0.001475404],"category_scores_gemma":[0.0001542783,0.0001364631,0.0002524403,0.00006137414,0.0001126812,0.0002950775,0.0001801637,0.0004599129,0.0005622577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815368,"about_ca_system_score_gemma":0.0001546493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003082696,"about_ca_topic_score_gemma":0.000392562,"domain_scores_codex":[0.9999142,0.00000969044,0.000006007722,0.00002066304,0.0000361053,0.00001341024],"domain_scores_gemma":[0.9999216,0.00001025437,0.00002420548,0.00001025726,0.00002301017,0.00001069606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001781402,0.000007142499,0.00002878611,0.00002263546,0.000002343683,0.00002220639,0.000005065829,0.0000723834,0.9983853,0.00003807758,0.00005408315,0.001344108],"study_design_scores_gemma":[0.00001161472,0.0003639382,0.0005595872,0.000004283104,0.000009943863,0.0001402995,0.000006147024,0.001475624,0.9944534,0.00002624092,0.00294263,0.000006352108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473739,0.003655023,0.04396528,0.0002485261,0.0002252173,0.0003005491,0.0006129437,0.0008472994,0.002771345],"genre_scores_gemma":[0.9663037,0.001282387,0.02811955,0.0001296903,0.00002906797,0.0001038034,0.0005436238,0.00008045299,0.003407786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475404,"threshold_uncertainty_score":0.004935682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563638587983506,"score_gpt":0.2738602613943049,"score_spread":0.2482238755144698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}